Results 201 to 210 of about 3,770,672 (358)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Computer-aided quantitative stromal analysis: a comprehensive investigation of its prognostic significance in lung squamous cell carcinoma. [PDF]

Transl Lung Cancer Res
Zhang X, Chen J, Bu X, Huang Q, Li Y, Zhang D, Yang J, Feng A, Meng F, Li W, Sun Q, Xu C.   +11 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Computer-aided prediction of growth in vestibular schwannomas based on both structural and dynamic contrast-enhanced MR imaging. [PDF]

Med Phys
Cornelissen S, Schouten SM, Lewis D, Li KL, Zhu X, Maas MC, Pegge S, Jansen TTG, Mulder JJS, Langenhuizen PPJH, King AT, Verheul JB, Kunst HPM, De With PHN.   +13 more
europepmc   +1 more source

Computer aided designer, simulation and testing of cooling system in electronic devices [PDF]

, 2015
Sławomir Łuniewski
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Bridging the gap: Computer-aided detection and Yamada classification system matches expert performance. [PDF]

World J Gastroenterol
Qiu L, Ding J, Lai CX, Yang H, Li F, Li ZJ, Wu W, Liu GM, Guan QS, Zhang XG, Zhang RY, Yi LZ, Zhao ZF, Deng L, Lun WJ, Wang ZY, Lu WM, Qiao WG, Wang SL, Chen SM, Shen WQ, Cheng LM, Zhu BG, He SH, Dai J, Bai Y.   +25 more
europepmc   +1 more source

MACHINE LEARNING BASED ANALYSIS AND COMPUTER AIDED CLASSIFICATION OF NEUROPSYCHIATRIC DISORDERS USING NEUROIMAGING

, 2019
Tewodros Mulugeta Dagnew
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Computer-aided design of piezoelectric systems operating as machine assemblies or subassemblies. [PDF]

Sci Rep
Harazin J, Wróbel A.
europepmc   +1 more source