Results 81 to 90 of about 445,823 (307)

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

International Journal of Polymer Science, 2020
We report on the synthesis of chitosan-alginate nanodisks (Cs-Al NDs) using a simple approach consisting of the ionotropic gelation method. Sodium tripolyphosphate (STPP) was used as crosslinking agent to promote the electrostatic interaction between ...
David Patiño-Ruiz, Leandro Marrugo, Niradiz Reyes, María Acevedo-Morantes, Adriana Herrera   +4 more
doaj   +1 more source

Supporting reinterpretation in computer-aided conceptual design [PDF]

, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder), Chase, S., EPSRC (Funder), Garner, S., Jowers, I., Lim, S., McKay, A., Prats, M.   +7 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Molding Characteristics and Impact Strength of Polypropylene with Different Numbers of Recycling Cycles

Engineering Proceedings
We analyzed the changes in the molding properties of polypropylene (PP) resin in the process of recycling after multiple plasticization, injection, and crushing processes.
Hui-Mei Zheng, Jui-Chan Li, Yen-Kai Wang, Kai-Fu Liew, Hsin-Shu Peng   +4 more
doaj   +1 more source

Modeling and Analysis of Power Processing Systems (MAPPS). Volume 1: Technical report [PDF]

Computer aided design and analysis techniques were applied to power processing equipment. Topics covered include: (1) discrete time domain analysis of switching regulators for performance analysis; (2) design optimization of power converters using ...
Carter, R. A., Chang, R., Lee, F. C., Rahman, S., Wu, C. H., Yu, Y.   +5 more
core   +1 more source

Computer-aided design and analysis of mechanisms [PDF]

, 1982
An introduction to the computer programs developed to assist in the design and analysis of mechanisms is presented. A survey of the various types of programs which are available is given, and the most widely used programs are compared.
Knight, F. L.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

An Esthetics Rehabilitation with Computer-aided Design/ Computer-aided Manufacturing Technology

The Journal of Contemporary Dental Practice, 2014
ABSTRACT Aim This paper describes a case of a rehabilitation involving Computer Aided Design/Computer Aided Manufacturing (CADCAM) system in implant supported and dental supported prostheses using zirconia as framework. Background The CAD-CAM technology has developed considerably over last few years, becoming a reality in dental practice.
Mazaro, José Vitor Quinelli, Mello, Caroline Cantieri de, Zavanelli, Adriana Cristina, Santiago Junior, Joel Ferreira, Amoroso, Andressa Paschoal, Pellizzer, Eduardo Piza   +5 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Innovative Structural Optimization and Dynamic Performance Enhancement of High-Precision Five-Axis Machine Tools

Journal of Manufacturing and Materials Processing
To satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera, Tzu-Chi Chan, Jyun-Sian Yang   +2 more
doaj   +1 more source