Results 111 to 120 of about 423,955 (310)
Computer Aided Engineering of Cyber-Physical Information Gathering and Utilizing Systems [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 Engineering Cyber-physical information gathering and utilizing systems(CIGUS) presents the systems engineer with a difficult, multi-criterion, multi-objective decision problem.
Alfred P. Defonzo, Anthony P. Hopf
doaj
Computer Aided Design and Analysis in Die/Mould of Casting Process [PDF]
, 1997 Computer Aided Design (CAD) and Computer Aided Analysis (CAA) have been investigated and developed since the last twenty years as standalone systems.
Abedin, Md. Shamsul
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Large space antennas: A systems analysis case history [PDF]
The value of systems analysis and engineering is aptly demonstrated by the work on Large Space Antennas (LSA) by the NASA Langley Spacecraft Analysis Branch.
Keafer, Lloyd S., Lovelace, U. M.
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Construction of a Cutting-Tool Wear Prediction Model through Ensemble Learning
Applied SciencesThis study begins by conducting side milling experiments on SKD11 using tungsten carbide TiAlN-coated end mills to compare the surface roughness performance between two combinations of milling process parameters (feed rate and radial depth of cut), along
Shen-Yung Lin, Chia-Jen Hsieh
doaj +1 more source
NASA Tech Briefs, August 2000 [PDF]
Topics include: Simulation/Virtual Reality; Test and Measurement; Computer-Aided Design and Engineering; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery/Automation ...
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Stiffness and Lightweight Enhancement in Biomimetic Design of a Grinding Machine-Tool Structure
Applied SciencesAs global manufacturing faces rising energy costs, environmental pressures, and machining precision, the development trends of the machine tools are moving towards lightweight and high-rigidity structures.
Shen-Yung Lin, Yen-Ting Lai
doaj +1 more source