Results 141 to 150 of about 385,258 (306)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Computer-aided process analysis of an integrated biodiesel process incorporating reactive distillation and organic solvent nanofiltration

, 2015
To enable the use of alternative cheap feedstock in the production of biodiesel, such as waste cooking oils, the contained free fatty acids have to be separated from the triglycerides.
Skiborowski, Mirko, Werth, Kathrin, Neumann, Kolja   +2 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Modeling work processes in chemical engineering - from recording to supporting

, 2001
Published in: J. Grievink; J. van Schijndel (eds.): 'European Symposium on Computer Aided Process Engineering 12', Elsevier, (2002), p. 871-876SIGLEAvailable from TIB Hannover: RR 8872(2001,31) / FIZ - Fachinformationszzentrum Karlsruhe / TIB ...
Schneider, R., Eggersmann, M., Marquardt, W., Technische Hochschule Aachen (Germany). Lehrstuhl fuer Prozesstechnik   +3 more
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

SIGNS LANGUAGE IN GRAPHICAL COMMUNICATION MECHANICAL DRAWING: THE BASIC LANGUAGE IN GRAPHICAL COMMUNICATION

Journal of Industrial Design and Engineering Graphics, 2010
The paper presents general notions about graphical language used in engineering, the international standards used for representing objects and also the most important software applications used in Computer Aided Design for the development of products in ...
BADEA Florina, PETRESCU Ligia
doaj  

Computer - Aided Learning in Engineering Education

This paper discusses the role of computer-aided learning (CAL) in engineering education. In this study, some descriptions about computer aided learning were explained.
Seker, S
core  

Mechanism Analysis and Synthesis with Computer Aided Methods

, 2009
Main objective of this paper is further investigation of complex computer aided engineering tools and systems in defining and experimenting new methods of machine design. A four bar mechanism with pre-defined parameter set was designed using evolutionary
Kátai László, Szabó István
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source