Results 61 to 70 of about 805,019 (347)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Aplicación de metadatos Dublin Core a los principales módulos CAD de CATIA V5 [PDF]

open access: yes, 2009
CATIA, Computer Aided Three-dimensional Interactive Application, is one of the most important commercial software used for Computer Aided Design (CAD), Computer Aided Engineering (CAE), and Computer Aided Manufacturing (CAM) in the aerospace and ...
Martinez-Avila, Daniel
core   +1 more source

Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves [PDF]

open access: yes, 2009
We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph.
Fu, P.   +8 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Molding Characteristics and Impact Strength of Polypropylene with Different Numbers of Recycling Cycles

open access: yesEngineering Proceedings
We analyzed the changes in the molding properties of polypropylene (PP) resin in the process of recycling after multiple plasticization, injection, and crushing processes.
Hui-Mei Zheng   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

THE APPLICATION OF COMBINATORIAL-VARIATIONAL APPROACH TO COMPUTER GEOMETRICAL MODELING OF ENGINEERING CONSTRUCTIONS AND BUILDINGS

open access: yesStructural Mechanics of Engineering Constructions and Buildings, 2013
The paper considers some issues of combinatorial-variational geometric modeling for computer-aided formation of engineering constructions and buildings in their design using modern computer-aided approach.
Vladimir VLADIMIROVICh Vanin   +2 more
doaj  

A two-stage multi-scale attention-based network for weakly supervised cataract fundus image enhancement

open access: yesScientific Reports
Cataract is a major cause of vision loss and hinders further diagnosis. However, enhancing cataract fundus images remains challenging due to limited paired cataract retinal images and the difficulty of recovering fine details in the retinal images.
Xiaoyong Fang   +4 more
doaj   +1 more source

Energy Integration and WEP Technical Evaluation of a Large-Scale PVC Production Process

open access: yesSci
PVC has become an indispensable material worldwide. However, its production method (suspension) presents significant sustainability challenges, such as negative environmental impacts and high operational costs due to energy consumption.
Antonio Mendivil-Arrieta   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy