Results 61 to 70 of about 424,101 (310)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Selective laser sintering and its application in biomedical engineering [PDF]

, 2011
Rapid prototyping (RP) technologies, which are based on computer-aided design and computer-aided manufacturing, are widely employed in traditional industries.
Duan, B, Wang, M
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A Metamodel for the Rubus Component Model: Extensions for Timing and Model Transformation From EAST-ADL

IEEE Access, 2017
According to the model-driven engineering paradigm, one of the entry requirements when realizing a seamless tool chain for the development of software is the definition of metamodels, to regulate the specification of models, and model transformations ...
Alessio Bucaioni, Antonio Cicchetti, Federico Ciccozzi, Saad Mubeen, Mikael Sjodin   +4 more
doaj   +1 more source

On the Evolution of CAE Research [PDF]

, 1994
Less than a decade ago it seemed that a new paradigm of engineering–called computer-aided engineering (CAE) – was emerging. This emergence was driven in part by the success of computer support for the tasks of engineering analysis and in part by a new ...
Dym, Clive L., Levitt, Raymond E.
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Computer Aided Modeling and Post Processing with NASTRAN Analysis [PDF]

Computer aided engineering systems are invaluable tools in performing NASTRAN finite element analysis. These techniques are implemented in both the pre-processing and post-processing phases of the NASTRAN analysis.
Boroughs, R. R.
core   +1 more source

Design and structural optimisation of a tractor mounted telescopic boom crane [PDF]

, 2016
In this research, an application algorithm, which can be used in computer-aided design/engineering (CAD/CAE) and structural optimisation-based design studies of agricultural machineries, is introduced. This developed algorithm has been put in practice in
Akinci, Ibrahim, Celik, H. Kursat, Rennie, Allan Edward Watson   +2 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Innovative Structural Optimization and Dynamic Performance Enhancement of High-Precision Five-Axis Machine Tools

Journal of Manufacturing and Materials Processing
To satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera, Tzu-Chi Chan, Jyun-Sian Yang   +2 more
doaj   +1 more source