Results 231 to 240 of about 2,559,571 (361)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Dyadic Neural Synchronization: Differences between Offline and Computer-assisted Online Verbal Interaction. [PDF]

Hum Brain Mapp
Hu S, Zhang P, Fang Y, Gong X, Fu L, Ma E, Zhou D, Lv Z, Valdes-Sosa PA.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2016

Lecture Notes in Computer Science, 2016
S. Ourselin, Leo Joskowicz, M. Sabuncu, Gozde Unal, W. Wells   +4 more
semanticscholar   +1 more source

Computer-Assisted Planning and Navigation of Osteotomies in Rhinoplasty: An Innovative Technique. [PDF]

Laryngoscope Investig Otolaryngol
Mirallié M, De Bonnecaze G, Chaput B, Radulesco T, Michel J, Vergez S, Vairel B.   +6 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Computer-Assisted Text Analysis for Comparative Politics

Political Analysis, 2015
Christopher Lucas, Richard Nielsen, Margaret E. Roberts, Brandon M Stewart, Alex Storer, D. Tingley   +5 more
semanticscholar   +1 more source

Computer-assisted cognitive training in children with developmental disorders: a scoping review of available tools, clinical targets, and evidence gaps. [PDF]

Front Pediatr
Maggio MG, Ettorre P, Benenati A, Ciancarelli I, Di Iulio F, Iosa M, Calabrò RS, Morone G.   +7 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source