Results 261 to 270 of about 550,093 (335)

Safety and accuracy assessment of static computer assisted localized piezoelectric alveolar decortication: an in vitro study. [PDF]

Clin Oral Investig
Lara-Muros M, Camps-Font O, Vilarrasa J, Vilarrasa J, Mir-Mari J, Figueiredo R, Valmaseda-Castellón E.   +6 more
europepmc   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, Volume 15, Issue 5, Page 738-753, May 2025.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, Volume 15, Issue 5, Page 763-772, May 2025.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

CAD-PsorNet: deep transfer learning for computer-assisted diagnosis of skin psoriasis. [PDF]

Sci Rep
Chakraborty C, Achar U, Nayek S, Achar A, Mukherjee R.   +4 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

, 1985
Rafael Mattera, Barry J.R. Pitts, Mark L. Entman, Lutz Birnbaumer   +3 more
openalex   +1 more source

Cost-Effectiveness of Computer-Assisted Cytology in a Primary hrHPV-Based Cervical Cancer Screening Programme. [PDF]

Cancer Med
Olthof EMG, Kaljouw S, van Kemenade FJ, Uyterlinde AM, de Kok IMCM.   +4 more
europepmc   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, Volume 15, Issue 5, Page 793-809, May 2025.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Multicentre, real-world data of next-generation computer-assisted vacuum aspiration thrombectomy in acute pulmonary embolism. [PDF]

Respir Res
Sławek-Szmyt S, Stępniewski J, Kurzyna M, Klaudel J, Kuliczkowski W, Lewandowski M, Grabka M, Roik M, Ordiene R, Jankiewicz S, Kopeć G, Darocha S, Mroczek E, Widecka K, Kurzyna P, Lesiak M, Pruszczyk P, Araszkiewicz A.   +17 more
europepmc   +1 more source