Results 61 to 70 of about 5,439,941 (279)

Machine Learning Methods for Histopathological Image Analysis

Computational and Structural Biotechnology Journal, 2018
Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine learning techniques.
Daisuke Komura, Shumpei Ishikawa
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Estimation and Evaluation of New Features from Phonocardiogram for Detecting Cardiovascular Abnormalities

مجله دانشکده پزشکی اصفهان, 2019
Background: In the world, cardiovascular diseases are the major cause of death, as 31% of global mortality is from them. Due to problems such as the lack of technologies such as echocardiography, and limited access to cardiologists in deprived areas ...
Mahdi Nourian-Zavareh, Saeed Kermani, Mohammad Hashemi-Jazi, Maryam Samieinasab   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Accuracy and Precision in Computer-Assisted Methods for Orthopaedic Surgery

, 2015
This chapter reviews the major approaches to the definition of bone cutting accuracy in the field of computer-assisted orthopaedic surgery. The first part of the chapter reviews the different concepts of accuracy found in literature, from localization in
Federico E. Milano, Cartiaux, Olivier, Milano, Federico, Olivier Cartiaux   +3 more
core   +1 more source

Role of Computer Aided Diagnosis (CAD) in Medical Imaging

Central Asian Journal of Medical Sciences, 2015
Objectives: We introduce the various methods of image analysis used for CAD. In addition, we provide a guide for the clinician through examples which use the CAD.
Seung Won Shin, Kwang Gi Kim
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Asia-Pacific consensus on the use of artificial intelligence in colorectal cancer screening and surveillance

iGIE
Background and Aims: Artificial intelligence (AI)-assisted colonoscopy has been widely investigated for colorectal adenoma and cancer detection and characterization.
Frederick H. Koh, PhD, James W. Li, MD, Sunny H. Wong, DPhil, Jonathan Lee, MD, Sneha John, FRACP, Vui Heng Chong, MD, Kai-chun Wu, MD, Rashid Lui, FRCP, Simon S.M. Ng, MD, Thomas Y.T. Lam, PhD, Louis H.S. Lau, MBChB, Govind K. Makharia, MD, Murdani Abdullah, MD, Hasan Maulahela, MD, Nozomu Kobayashi, MD, Masau Sekiguchi, MD, Jeong-Sik Byeon, MD, Hyun-soo Kim, MD, Yeong Yeh Lee, MD, Han-Mo Chiu, MD, I-Chen Wu, MD, Somchai Leelakusolvong, MD, Prateek Sharma, MD, David Lieberman, MD, Joseph J.Y. Sung, MD   +24 more
doaj   +1 more source