Results 91 to 100 of about 17,096,706 (238)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A brief summary of digital image enhancement [PDF]
Digital image processing is a modern branch of computer application. With the help of computers the visual quality of original images which were blurred by external interferences or optical transfer function of transmission channel can be improved so ...
Qiang, Gu Yun
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, 2013 International audienceThis book constitutes the proceedings of the 4th International Conference on Information Processing in Computer-Assisted Interventions IPCAI 2013, held in Heidelberg, Germany, on June 26, 2013. The 11 papers presented were carefully
Jannin, Pierre +4 more
core +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Patologìâ, 2017 Сomputer automatic diagnostic (CAD)/classification of video – images is actual for laparoscopic surgery. Such CAD is supposed to explore intraoperatively for support surgeon decisions. Aim: to evaluate the effectiveness of the CAD systems developed on
D. N. Bayazitov +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A heterogeneous pyramid array architecture for image understanding [PDF]
This paper describes a massively parallel architecture for image understanding and computer vision. A key issue in these applications is the transition from iconic to more abstract symbolic data representations.
Howarth, Rolf M.
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Zdravniški Vestnik, 2017 Background: Vertebral fixation by pedicle screw placement is the most frequently applied fixation technique in spinal surgery. In this retrospective study we present a comparison of manual and computer-assisted preoperative planning of pedicle screw ...
Dejan Knez +5 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A stochastic model for automatic extraction of 3D neuronal morphology.
, 2013 Medical image computing and computer-assisted intervention : MICCAI ...
Ooi, W.T. +9 more
core +1 more source