Results 31 to 40 of about 646,393 (224)

Quantitative Analysis of the Time–Intensity Curve of Contrast-Enhanced Ultrasound of the Liver: Differentiation of Benign and Malignant Liver Lesions

Diagnostics, 2021
Background: To evaluate the diagnostic accuracy of quantitative perfusion parameters in contrast-enhanced ultrasound to differentiate malignant from benign liver lesions.
Sonja Schwarz, Dirk-André Clevert, Michael Ingrisch, Thomas Geyer, Vincent Schwarze, Johannes Rübenthaler, Marco Armbruster   +6 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

An effective and open source interactive 3D medical image segmentation solution

Scientific Reports
3D medical image segmentation is a key step in numerous clinical applications. Even though many automatic segmentation solutions have been proposed, it is arguably that medical image segmentation is more of a preference than a reference as inter- and ...
Yi Gao, Xiaohui Chen, Qinzhu Yang, Andras Lasso, Ivan Kolesov, Steve Pieper, Ron Kikinis, Allen Tannenbaum, Liangjia Zhu   +8 more
doaj   +1 more source

True color night vision correlated imaging based on intensity correlation of light [PDF]

arXiv, 2021
Night vision imaging is a technology that converts non-visible object to human eyes into visible image in night and other low light environments. However, the conventional night vision imaging can only directly produce grayscale image. Here, we propose a novel night vision imaging method based on intensity correlation of light. The object's information
arxiv  

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Compresión de imágenes médicas

Biomédica: revista del Instituto Nacional de Salud, 2013
La medicina moderna es una actividad cada vez más compleja, basada en la información proveniente de múltiples fuentes: historias clínicas, dictáfonos e imágenes y vídeos provenientes de múltiples dispositivos.
Tatiana Noreña, Eduardo Romero
doaj   +1 more source

Computer-Assisted Screening for Cervical Cancer Using Digital Image Processing of Pap Smear Images

Applied Sciences, 2020
Cervical cancer can be prevented by having regular screenings to find any precancers and treat them. The Pap test looks for any abnormal or precancerous changes in the cells on the cervix.
Kyi Pyar Win, Yuttana Kitjaidure, Kazuhiko Hamamoto, Thet Myo Aung   +3 more
doaj   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source