Results 91 to 100 of about 12,884 (200)

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Oncologic Safety of Facial‐Vessel–Based Buccinator Myomucosal Flaps for Tongue and Oral Floor Reconstruction: A Retrospective Multicenter Case–Control Study

Head &Neck, EarlyView.
ABSTRACT Background Buccinator myomucosal flaps (BMFs) have been proposed as a reconstructive solution for defects of the tongue and oral floor; however, their harvest requires preservation of the facial artery and vein. This study aimed to evaluate the oncologic safety of this approach compared with free fasciocutaneous flaps (FFF).
Luigi Angelo Vaira, Olindo Massarelli, Jerry Polesel, Andrea Ferri, Carlos M. Chiesa‐Estomba, Ignacio Navarro Cuéllar, Giuseppe Consorti, Giulio Cirignaco, Marco Cucurullo, Giovanni Salzano, Sourabh Padmanabhan, Abhijith George, Marzia Petrocelli, Javeria Ali, Jose A. González‐Garcia, Alfonso Manfuso, Tareck Ayad, Carlos Navarro Cuéllar, Fabiola Giudici, Jerome R. Lechien, Shawn T. Joseph, Chiara Copelli, Federico Biglioli, Silvano Ferrari, Giacomo De Riu   +24 more
wiley   +1 more source

Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023.
Koichiro Nakajima, Hiromitsu Iwata, Gaku Takano, Daiki Kojima, Yukiko Hattori, Yusuke Tsuzuki, Shuou Sudo, Kensuke Hayashi, Toshiyuki Toshito, Hideo Fukano, Hiroyuki Ogino, Akio Hiwatashi   +11 more
wiley   +1 more source

Guided Implant Surgery in Oral Cancer Patients: Initial Clinical Experience from an Academic Point-of-Care Manufacturing Unit. [PDF]

Medicina (Kaunas)
Tousidonis M, Salmeron JI, Ochandiano S, Perez-Mañanes R, Gomez-Larren E, Aguilera-Jimenez E, de Gregorio-Bermejo C, Fernández-Acosta D, Gonzalez-Moure B, Khayat S, Navarro-Cuellar C.   +10 more
europepmc   +1 more source

Nomogram for Predicting Osteoradionecrosis After Fibula Free Flap for Mandibular Reconstruction

Head &Neck, EarlyView.
ABSTRACT Background Osteoradionecrosis (ORN) is a severe complication following radiotherapy (RT), particularly after mandibular reconstruction with a fibula free flap. Risk prediction remains challenging due to limited data. Methods We conducted a multicenter retrospective study including 294 patients who underwent fibula free flap reconstruction and ...
Andrea Costantino, Bianca Festa, Filippo Marchi, Chung‐Kan Tsao, Raul Pellini, Luca Gazzini, Peter T. Dzięgielewski, Mario Ciniglio, Francesco Mazzola, Luca Calabrese, Antonio Sarno, Giampiero Parrinello, Linda Chow, Jyh‐Kwei Chen, Giorgio Peretti, Armando De Virgilio   +15 more
wiley   +1 more source

Advances in Artificial Intelligence for Glioblastoma Radiotherapy Planning and Treatment. [PDF]

Cancers (Basel)
Master R, Rubin N, Sampson J, Yadav KK, Pandita S, Sabbagh A, Krishnan A, Silva PJ, Ramos KS, Gregoire V, Paragios N, Krishnan S, Pandita TK.   +12 more
europepmc   +1 more source

Greater Attention to Gingival Cancer and Floor of Mouth Cancer: Based on a Retrospective Analysis of Oral Cancer Across Different Subsites

Head &Neck, EarlyView.
ABSTRACT Background The gingiva and floor of the mouth are distinct subsites, and oral squamous cell carcinoma (OSCC) originating in these locations warrants further indepth understanding. Methods This study enrolled patients with OSCC from 2000 to 2020, and analyzed the clinicopathological characteristics.
Hao Li, Yi Ding, Yansheng Wu, Yan Fang, Xinhua Li, Weifeng Shi, Shaoshi Chen, Ailin Yang, Jin Zhang, Ruoyu Shi, Chao Jing, Xudong Wang, Yuansheng Duan   +12 more
wiley   +1 more source

Clinical validation of AI-assisted contouring in prostate radiation therapy treatment planning: Highlighting automation bias and the need for standardized quality assurance. [PDF]

J Appl Clin Med Phys
Arjmandi N, Sebzari AR, Molaei F, Rezaei S, Rezaie-Yazdi M, Rezaie-Yazdi M.   +5 more
europepmc   +1 more source