Results 51 to 60 of about 295,010 (247)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Computer aided vertebral visualization and analysis: a methodology using the sand rat, a small animal model of disc degeneration

BMC Musculoskeletal Disorders, 2003
Background The purpose of this study is to present an automated system that analyzes digitized x-ray images of small animal spines identifying the effects of disc degeneration.
Hanley Edward N, Najarian Kayvan, Brown Darien, Wilson Christy, Gruber Helen E   +4 more
doaj   +1 more source

Multi-Person Brain Activity Recognition via Comprehensive EEG Signal Analysis

, 2017
An electroencephalography (EEG) based brain activity recognition is a fundamental field of study for a number of significant applications such as intention prediction, appliance control, and neurological disease diagnosis in smart home and smart ...
Gu, Tao, Sheng, Quan Z., Wang, Xianzhi, Yao, Lina, Zhang, Dalin, Zhang, Xiang   +5 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The clinical applications of brain–computer interfaces

Brain-X
With the establishment of interdisciplinary platforms in medical engineering, the twenty‐first century has witnessed rapid advancements in brain‒computer interface (BCI) technology, demonstrating significant potential in clinical applications.
Chao‐Ran Jia, Jian‐Wei Huang, Ying‐Qing Hu, Hai‐Yun Zhou, Hong‐Yu Liu, Xin Liu, Hai Zhang, Zu‐Cheng Shen, Wen‐Sheng Li, Shuang‐Qi Gao, Ying Guo   +10 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Computerized invasive measurement of time-dependent intraocular pressure

Brazilian Journal of Medical and Biological Research, 2006
Several methods have been described to measure intraocular pressure (IOP) in clinical and research situations. However, the measurement of time varying IOP with high accuracy, mainly in situations that alter corneal properties, has not been reported ...
T.V.O. Campos, S. Jacobovitz, H.G. Almeida, A.R. Massensini, M.F.D. Moraes   +4 more
doaj  

An Open CAPT System for Prosody Practice: Practical Steps towards Multilingual Setup

Languages
This paper discusses the challenges posed in creating a Computer-Assisted Pronunciation Training (CAPT) environment for multiple languages. By selecting one language from each of three different language families, we show that a single environment may be
John Blake, Natalia Bogach, Akemi Kusakari, Iurii Lezhenin, Veronica Khaustova, Son Luu Xuan, Van Nhi Nguyen, Nam Ba Pham, Roman Svechnikov, Andrey Ostapchuk, Dmitrei Efimov, Evgeny Pyshkin   +11 more
doaj   +1 more source