Results 61 to 70 of about 885,099 (311)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A Time Comparison of Computer-Assisted and Manual Bathymetric Processing [PDF]

, 2004
We describe an experiment designed to determine the time required to process Multibeam Echosounder (MBES) data using the CUBE (Combined Uncertainty and Bathymetry Estimator) [Calder & Mayer, 2003; Calder, 2003] and Navigation Surface [Smith et al., 2002;
Calder, Brian R., Smith, Shep
core   +2 more sources

Recent trends, technical concepts and components of computer-assisted orthopedic surgery systems: A comprehensive review [PDF]

, 2019
Computer-assisted orthopedic surgery (CAOS) systems have become one of the most important and challenging types of system in clinical orthopedics, as they enable precise treatment of musculoskeletal diseases, employing modern clinical navigation systems ...
Kalová, Martina, Kubíček, Jan, Oczka, David, Tomanec, Filip, Vilímek, Dominik, Černý, Martin   +5 more
core   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

Computer aided vertebral visualization and analysis: a methodology using the sand rat, a small animal model of disc degeneration

BMC Musculoskeletal Disorders, 2003
Background The purpose of this study is to present an automated system that analyzes digitized x-ray images of small animal spines identifying the effects of disc degeneration.
Hanley Edward N, Najarian Kayvan, Brown Darien, Wilson Christy, Gruber Helen E   +4 more
doaj   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, Volume 599, Issue 8, Page 1146-1158, April 2025.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Recommendations for standardization and specifications in automated electrocardiography: bandwidth and digital signal processing. A report for health professionals by an ad hoc writing group of the Committee on Electrocardiography and Cardiac Electrophysiology of the Council on Clinical Cardiology,

Circulation, 1990
R ecent technologic advances and published studies point to the need to reevaluate requirements for recording and analysis of electrocardiographic (ECG) data. Several issues have arisen from recent developments.
J. Bailey, A. Berson, A. Garson, L. Horan, P. Macfarlane, D. Mortara, C. Zywietz   +6 more
semanticscholar   +1 more source

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl, Ali Asghar Hakami Zanjani, Himanshu Khandelia   +2 more
wiley   +1 more source

An Open CAPT System for Prosody Practice: Practical Steps towards Multilingual Setup

Languages
This paper discusses the challenges posed in creating a Computer-Assisted Pronunciation Training (CAPT) environment for multiple languages. By selecting one language from each of three different language families, we show that a single environment may be
John Blake, Natalia Bogach, Akemi Kusakari, Iurii Lezhenin, Veronica Khaustova, Son Luu Xuan, Van Nhi Nguyen, Nam Ba Pham, Roman Svechnikov, Andrey Ostapchuk, Dmitrei Efimov, Evgeny Pyshkin   +11 more
doaj   +1 more source