Results 141 to 150 of about 285,490 (299)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Intelligent medicine in focus: the 5 stages of evolution in robot-assisted surgery for prostate cancer in the past 20 years and future implications

Military Medical Research
Robot-assisted surgery has evolved into a crucial treatment for prostate cancer (PCa). However, from its appearance to today, brain-computer interface, virtual reality, and metaverse have revolutionized the field of robot-assisted surgery for PCa ...
Jia-Kun Li, Tong Tang, Hui Zong, Er-Man Wu, Jing Zhao, Rong-Rong Wu, Xiao-Nan Zheng, Heng Zhang, Yi-Fan Li, Xiang-Hong Zhou, Chi-Chen Zhang, Zi-Long Zhang, Yi-Hang Zhang, Wei-Zhe Feng, Yi Zhou, Jiao Wang, Qi-Yu Zhu, Qi Deng, Jia-Ming Zheng, Lu Yang, Qiang Wei, Bai-Rong Shen   +21 more
doaj   +1 more source

The Future of ORLHNS and Associated Specialties Series: The future of rhinology, anterior skull base and facial plastic surgery [PDF]

, 2002
Lund, VJ, Rowe-Jones, JM
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Effect of Computer-Assisted Cognitive Remediation Therapy on Cognition Among Patients With Schizophrenia: A Pilot Randomized Controlled Trial

Ayumi Yamanushi, Takeshi Shimada, Ami Koizumi, Masayoshi Kobayashi   +3 more
openalex   +3 more sources

Hormone Replacement Therapy – Computer Assisted Individualized Approach [PDF]

, 2018
BM Petrikovsky
openalex   +1 more source

The efficacy of computer-assisted cognitive behavioral therapy (cCBT) on psychobiological responses and perioperative outcomes in patients undergoing functional endoscopic sinus surgery: a randomized controlled trial [PDF]

, 2021
Yang Yang, Yuling Li, Haibin Zhang, Yong Xu, Binquan Wang   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The third wave of cognitive behavioral therapy and the rise of process-based care [PDF]

, 2017
Arch, Arch, Hayes, Hofmann, Hofmann, Insel, Khoury, Klepac, Wolitzky-Taylor   +8 more
core   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source