Results 31 to 40 of about 976,513 (253)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Comparison between TACS and CBTC System Degradation Impacts in Urban Rail Transit
Chengshi guidao jiaotong yanjiu[Objective] To meet increasing urban rail transit capacity demands, traditional CBTC (communication-based train control) signaling systems-with ground-based interlocking as core architecture-are evolving toward TACS (train autonomous circumnavigation ...
WANG Chen +4 more
doaj +1 more source
Fluoroscopic freehand and electromagnetic-guided targeting system for distal locking screws of humeral intramedullary nail [PDF]
, 2016 Purpose The current techniques used to lock distal screws for the nailing of long bone fractures expose the surgeons, radiologists and patients to a hearty dose of ionizing radiation.
Di Giacomo, Giorgio +4 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Towards Model Checking Executable UML Specifications in mCRL2 [PDF]
, 2009 We describe a translation of a subset of executable UML (xUML) into the process algebraic specification language mCRL2. This subset includes class diagrams with class generalisations, and state machines with signal and change events.
A Cimatti +11 more
core +8 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Analysis on Computer Interlocking Logic Design for Main Line of Urban Rail Transit
机车电传动, 2012 Function of computer interlocking equipment, which was considered as one of core subsystem of signal system was discussed. Moreover, in terms of practical requirement, a modified method of interlocking logic realization was proposed.
LIANG Yun-peng, WANG Cheng, LV Hao-jiong
doaj
Standardized Testing of Non-Standard Photovoltaic Pavement Surfaces [PDF]
, 2016 Emerging photovoltaic products have expanded the applications for the technologies into markets previously unconsidered for what was thought to be a delicate electronic product.
Coutu, Ronald A., Jr. +2 more
core +2 more sources