Results 41 to 50 of about 976,513 (253)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
From Poincare to affine invariance: How does the Dirac equation generalize? [PDF]
, 2001 A generalization of the Dirac equation to the case of affine symmetry, with SL(4,R) replacing SO(1,3), is considered. A detailed analysis of a Dirac-type Poincare-covariant equation for any spin j is carried out, and the related general interlocking ...
Corson E M +13 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Modelling of Failure Effect to Integrity of System
Advances in Electrical and Electronic Engineering, 2004 The interlocking systems are typically resisting against hazardous faults. Failure effect on the system can be determined directly by monitoring the original system installation, by simulation of the system operation using its model, or by computing or ...
Karol Rastocny
doaj
Research on the Solution of Train-trackside CooperativeShortening Movement Authority
Kongzhi Yu Xinxi Jishu, 2020 In railway operations, when an opened route needs to be closed occasionally, the approach locking function of interlocking is needed to avoid the trip risk of a train.
LI Qihe
doaj
An assessment of the remodelling of bifurcations in hazel (Corylus avellana L.) in response to bracing, drilling and splitting [PDF]
, 2016 This paper provides an insight into the ability of bifurcations in hazel trees to remodel themselves after bracing, drilling and splitting. The study uses evidence from field observations and testing the strength of these bifurcations using a universal ...
Ennos, A R, Slater, Daniel
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Prognostic Evaluation Model and Application for Computer Interlocking System
机车电传动, 2018 Computer interlocking system plays an important role in railway, but its breakdown maintenance cannot stratify requirements of fast developing railway. Prediction model was developed based on mathematical model of components and entire system fault tree ...
FENG Haonan +4 more
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