Results 91 to 100 of about 2,182,933 (405)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Non-uniform FIR Digital Filter Bank for Hearing Aid Application Using Frequency Response Masking Technique: A Review [PDF]

arXiv, 2020
Hearing aid is an electroacoustic device used to selectively amplify the audio sounds with an aim to make speech more intelligible for a hearing impaired person. Filter bank is one of the important parts of digital hearing aid where the sub band gains of each filter can be tuned to compensate an individuals unique hearing loss pattern.
arxiv  

Exploratory Landscape Validation for Bayesian Optimization Algorithms

Mathematics
Bayesian optimization algorithms are widely used for solving problems with a high computational complexity in terms of objective function evaluation. The efficiency of Bayesian optimization is strongly dependent on the quality of the surrogate models of ...
Taleh Agasiev, Anatoly Karpenko
doaj   +1 more source

Supporting reinterpretation in computer-aided conceptual design [PDF]

, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder), Chase, S., EPSRC (Funder), Garner, S., Jowers, I., Lim, S., McKay, A., Prats, M.   +7 more
core  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Improving the translation environment for professional translators [PDF]

, 2019
When using computer-aided translation systems in a typical, professional translation workflow, there are several stages at which there is room for improvement. The SCATE (Smart Computer-Aided Translation Environment) project investigated several of these
Augustinus, Liesbeth, Bulté, Bram, Buysschaert, Joost, Coppers, Sven, Daems, Joke, Heyman, Geert, Hoste, Veronique, Lefever, Els, Luyten, Kris, Macken, Lieve, Moens, Marie-Francine, Pelemans, Joris, Rigouts Terryn, Ayla, Steurs, Frieda, Tezcan, Arda, Van den Bergh, Jan, van der Lek-Ciudin, Iulianna, Van Eynde, Frank, Vanallemeersch, Tom, Vandeghinste, Vincent, Verwimp, Lyan, Wambacq, Patrick   +21 more
core   +2 more sources

A Novel Computer-Aided Design/Computer-Assisted Manufacture Method for One-Piece Removable Partial Denture and Evaluation of Fit.

International Journal of Prosthodontics, 2018
PURPOSE To investigate a computer-aided design/computer-aided manufacturing (CAD/CAM) process for producing one-piece removable partial dentures (RPDs) and to evaluate their fits in vitro.
H. Ye, Xinxin Li, Guanbo Wang, Jing Kang, Yushu Liu, Yuchun Sun, Yongsheng Zhou   +6 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Taking Advice from (Dis)Similar Machines: The Impact of Human-Machine Similarity on Machine-Assisted Decision-Making [PDF]

arXiv, 2022
Machine learning algorithms are increasingly used to assist human decision-making. When the goal of machine assistance is to improve the accuracy of human decisions, it might seem appealing to design ML algorithms that complement human knowledge. While neither the algorithm nor the human are perfectly accurate, one could expect that their complementary
arxiv  

Investigation of Air Transportation Technology at Princeton University, 1989-1990 [PDF]

, 1990
The Air Transportation Technology Program at Princeton University proceeded along six avenues during the past year: microburst hazards to aircraft; machine-intelligent, fault tolerant flight control; computer aided heuristics for piloted flight ...
Stengel, Robert F.
core   +1 more source