Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Decision Support System for Wind Farm Maintenance Using Robotic Agents
Applied System InnovationThe automation of wind turbine maintenance processes is aimed at improving the operational efficiency of wind farms through timely diagnosis of technical condition, predictive identification of potential failures, and optimization of the distribution of ...
Vladimir Kureichik +3 more
doaj +1 more source
Computer-aided electronic circuit design. Conduction processes in thin films Status report, 1 Dec. 1965 - 31 May 1966 [PDF]
Computer aided electronic circuit design and conduction processes in thin ...
core +1 more source
A pentagonal surface patch for computer-aided geometric design [PDF]
, 1981 A vector valued interpolation scheme for a pentagon is described which is compatible with surface patches which have a rectangular domain of definition. Such a scheme could be useful in computer- aided geometric design problems, where a pentagonal patch ...
Charrot, P, Gregory, JA
core
The Journal of Computer-Aided Molecular Design: a bibliometric note [PDF]
, 2011 Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer-Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily
Willett, P.
core +2 more sources
COMPUTER-AIDED DESIGN OF THE VIVALDI ANTENNA FOR ULTRA-WIDEBAND ELECTROMAGNETIC PULSE RADIATION
, 2021 A.I. Mel’nichuk +2 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
European Pharmaceutical JournalType 2 diabetes mellitus (T2DM), a degenerative disease characterized by insulin resistance, has been reported as a serious healthcare problem, especially in low-to-middle-income countries.
Riswanto Florentinus Dika Octa +9 more
doaj +1 more source
Improved Adaptive Routing Algorithm in Distributed Data Centers
Advances in Electrical and Electronic Engineering, 2017 Currently, telecom operators use virtualization of network infrastructure based on Data Centers (DCs). But when a company grows to a certain size and one DC is not sufficient, there are questions how to further develop the network infrastructure.
Dmitry Perepelkin, Maria Ivanchikova
doaj +1 more source
Computer-aided design and analysis of circuits and systems Final report, 20 Sep. 1966 - 1 Jul. 1968 [PDF]
Consolidation, standardization, and qualification of computer program routines associated with computer-aided design and analysis of circuits and ...
Henry, E. W.
core +1 more source