Results 101 to 110 of about 622,360 (336)

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems society information [PDF]

, 2022

openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Grid-based climate variability analysis of Addis Ababa, Ethiopia

Heliyon
Climate change is an intricate global environmental concern. However, its impact is more pervasive in developing nations such as Ethiopia. Hence, this manuscript examines temperature variability and the magnitude of change over 38 years in the specific ...
Esubalew Nebebe Mekonnen, Aramde Fetene, Ephrem Gebremariam   +2 more
doaj   +1 more source

Biodynamics of supine humans and interaction with transport systems during vibration and shocks

Journal of Low Frequency Noise, Vibration and Active Control, 2019
This work investigates the effect of the contact surfaces on the biomechanical response of supine humans during whole-body vibration and shocks. Twelve participants were exposed to three-dimensional random vibration and shocks and were tested with two ...
Salam Rahmatalla, Jonathan DeShaw, Khalid Barazanji   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Computer-aided electronic circuit design, part I. Conduction processes in thin films, part II Status report, 1 Jun. - 30 Nov. 1965 [PDF]

Computer-aided electronic circuit design, and conduction processes in thin ...

core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Joint Center Estimation Using Single-Frame Optimization: Part 2: Experimentation

Sensors, 2018
Human motion capture is driven by joint center location estimates, and error in their estimation can be compounded by subsequent kinematic calculations. Soft tissue artifact (STA), the motion of tissue relative to the underlying bones, is a primary cause
Eric Frick, Salam Rahmatalla
doaj   +1 more source

A bibliography on digital computer-aided circuit analysis and design [PDF]

Digital computer-aided electric logic circuit analysis and design ...
Yang, T.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source