Results 141 to 150 of about 622,360 (336)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Therapeutic Potential of Antiviral Peptides against the NS2B/NS3 Protease of Zika Virus

ACS Omega, 2023
Md. Shahadat Hossain, Md. Tanjil Islam Shovon, Md. Rafid Hasan, Fuad Taufiqul Hakim, Mohammad Mehedi Hasan, Sadia Afrose Esha, Sabiha Tasnim, Md. Shahoriar Nazir, Fahmida Akhter, Md Ackas Ali, Mohammad A. Halim   +10 more
doaj   +1 more source

Computer-Aided Cold Forging Process Design: A Knowledge-Based System Approach to Forming Sequence Generation

, 1988
P.F. Bariani, W.A. Knight
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Development of the computer-aided process planning (CAPP) system for polymer injection molds manufacturing [PDF]

, 2011
Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product.
D. Lukić, J. Tepić, M. Milošević, S. Borojević, V. Todić   +4 more
core  

Teaching Techniques In Computer Aided Design [PDF]

Jianping Yue
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Computer-Aided Design in Subtractive and Additive Prototyping [PDF]

, 2004
This paper concerns the use of a commercially available computer-aided design software in designing and manipulating the complex-shaped models for subtractive and additive prototyping processes.
M. Saleem, J. Hashmi, Sulaiman, Shamsuddin, Tang, Sai Hong, Wong, Su Luan, Young, Paul   +4 more
core  

High School Students' Written Argumentation Qualities with Problem-Based Computer-Aided Material (PBCAM) Designed about Human Endocrine System [PDF]

, 2017
Gülşah Sezen Vekli, Atilla Çimer
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source