Results 11 to 20 of about 884,023 (317)

MindSculpt: Using a Brain-Computer Interface to Enable Designers to Create Diverse Geometries by Thinking [PDF]

open access: yesProceedings of the 41st Annual Conference of the Association for Computer Aided Design in Architecture (ACADIA 2021), 2023
MindSculpt enables users to generate a wide range of hybrid geometries in Grasshopper in real time simply by thinking about those geometries. This design tool combines a brain-computer interface (BCI) with the parametric design platform Grasshopper, creating an intuitive design workflow that shortens the latency between ideation and implementation ...
arxiv   +1 more source

VR as a 3D Modelling Tool in Engineering Design Applications

open access: yesApplied Sciences, 2021
The study aims to explore the usefulness of existing VR 3D modelling tools for use in mechanical engineering. Previous studies have investigated the use of VR 3D modelling tools in conceptual phases of the product development process.
Daria Vlah, Vanja Čok, Uroš Urbas
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001

open access: yesMolecules, 2016
Ampakine compounds have been shown to reverse opiate-induced respiratory depression by activation of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors.
Dian Xiao   +6 more
doaj   +1 more source

Reducing the Concepts of Data Science and Machine Learning to Tools for the Bench Chemist

open access: yesCHIMIA, 2019
Machine Learning and Data Science have enjoyed a renaissance due to the availability of increased computational power and larger data sets. Many questions can be now asked and answered, that previously were beyond our scope.
Richard A. Lewis   +3 more
doaj   +1 more source

Maximal benefits and possible detrimental effects of binary decision aids [PDF]

open access: yes, 2020
Binary decision aids, such as alerts, are a simple and widely used form of automation. The formal analysis of a user's task performance with an aid sees the process as the combination of information from two detectors who both receive input about an event and evaluate it.
arxiv   +1 more source

Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

open access: yesCell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factors regulating ...
Pengyun Li   +12 more
doaj   +1 more source

Numerical Simulation of a High-Speed Impact of Metal Plates Using a Three-Fluid Model

open access: yesMetals, 2021
The process of wave formation at the contact boundary of colliding metal plates is a fundamental basis of explosive welding technology. In this case, the metals are in a pseudo-liquid state at the initial stages of the process, and from a mathematical ...
Petr Chuprov   +2 more
doaj   +1 more source

Integrating Deep Learning into CAD/CAE System: Generative Design and Evaluation of 3D Conceptual Wheel [PDF]

open access: yesStructural and Multidisciplinary Optimization, 64(4), pp. 2725-2747 (2021), 2020
Engineering design research integrating artificial intelligence (AI) into computer-aided design (CAD) and computer-aided engineering (CAE) is actively being conducted. This study proposes a deep learning-based CAD/CAE framework in the conceptual design phase that automatically generates 3D CAD designs and evaluates their engineering performance.
arxiv   +1 more source

Improving the binding affinity and interaction of 5-Pentyl-2-Phenoxyphenol against Mycobacterium Enoyl ACP reductase by computational approach

open access: yesInformatics in Medicine Unlocked, 2021
Tuberculosis (TB) is one of the leading causes of death worldwide. The development of new anti-tubercular drugs is required as resistant strains of M. tuberculosis to various first-line drugs are currently available.
Jakaria Shawon   +3 more
doaj  

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway

open access: yesMolecules, 2014
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells.
Xingzhou Li   +7 more
doaj   +1 more source

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