Results 21 to 30 of about 898,999 (335)
Molecules, 2016 Ampakine compounds have been shown to reverse opiate-induced respiratory depression by activation of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors.
Dian Xiao +6 more
doaj +1 more source
Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need
M. Salman +5 more
semanticscholar +1 more source
Determination of critical plane and assessment of fatigue durability for multiaxial cyclic loading and arbitrary shift of phases [PDF]
MATEC Web of Conferences, 2019 An analytical solution for the well-known fatigue criterion proposed by Papadopoulos was obtained. An arbitrary shift of phases was taken into account. Comparison between analytical, numerical solutions with experimental data was made.
Stratula Boris A. +3 more
doaj +1 more source
VR as a 3D Modelling Tool in Engineering Design Applications
Applied Sciences, 2021 The study aims to explore the usefulness of existing VR 3D modelling tools for use in mechanical engineering. Previous studies have investigated the use of VR 3D modelling tools in conceptual phases of the product development process.
Daria Vlah, Vanja Čok, Uroš Urbas
doaj +1 more source
Reducing the Concepts of Data Science and Machine Learning to Tools for the Bench Chemist
CHIMIA, 2019 Machine Learning and Data Science have enjoyed a renaissance due to the availability of increased computational power and larger data sets. Many questions can be now asked and answered, that previously were beyond our scope.
Richard A. Lewis +3 more
doaj +1 more source
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2020 The IEEE T RANSACTIONS ON C OMPUTER -A IDED D ESIGN OF I NTEGRATED C IRCUITS AND S YSTEMS publishes manuscripts focusing on methods, algorithms, and human-machine interfaces for physical and logical design, including: planning, synthesis, partitioning ...
semanticscholar +1 more source
Cell Death and Disease, 2022 Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factors regulating ...
Pengyun Li +12 more
doaj +1 more source
Numerical Simulation of a High-Speed Impact of Metal Plates Using a Three-Fluid Model
Metals, 2021 The process of wave formation at the contact boundary of colliding metal plates is a fundamental basis of explosive welding technology. In this case, the metals are in a pseudo-liquid state at the initial stages of the process, and from a mathematical ...
Petr Chuprov +2 more
doaj +1 more source
Molecules, 2014 A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells.
Xingzhou Li +7 more
doaj +1 more source
Journal of Combustion, 2018 The work is dedicated to the numerical study of detonation wave initiation and propagation in the variable cross-section axisymmetric channel filled with the model hydrogen-air mixture.
Alexander Lopato, Pavel Utkin
doaj +1 more source