Results 41 to 50 of about 593,733 (340)

Discoloration Resistance of Various Computer Aided Design/Computer Aided Manufacturing Restorative Materials

Essentials of Dentistry
Background: Evaluating the prolonged efficacy of restorative materials hinges significantly on their ability to resist discoloration. This study aims to assess the discoloration resistance of computer-aided design/computer-aided manufacturing restorative
Rana Turunç Oğuzman, Soner Şişmanoğlu   +1 more
doaj   +1 more source

Semi-Implicit Multistep Extrapolation ODE Solvers

Mathematics, 2020
Multistep methods for the numerical solution of ordinary differential equations are an important class of applied mathematical techniques. This paper is motivated by recently reported advances in semi-implicit numerical integration methods, multistep and
Denis Butusov, Aleksandra Tutueva, Petr Fedoseev, Artem Terentev, Artur Karimov   +4 more
doaj   +1 more source

Comparing Neural Style Transfer and Gradient-Based Algorithms in Brushstroke Rendering Tasks

Mathematics, 2023
Non-photorealistic rendering (NPR) with explicit brushstroke representation is essential for both high-grade imitating of artistic paintings and generating commands for artistically skilled robots.
Artur Karimov, Ekaterina Kopets, Tatiana Shpilevaya, Evgenii Katser, Sergey Leonov, Denis Butusov   +5 more
doaj   +1 more source

Computer-aided design and analysis of mechanisms [PDF]

, 1982
An introduction to the computer programs developed to assist in the design and analysis of mechanisms is presented. A survey of the various types of programs which are available is given, and the most widely used programs are compared.
Knight, F. L.
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

Molecules, 2015
The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this ...
Benjamin P. Cossins, Alastair D. G. Lawson   +1 more
doaj   +1 more source

A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein

Cell Death Discovery, 2021
Increasing evidence suggests the pivotal role of hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) in cancer development and progression, indicating that HPIP inhibition may be a promising target for cancer ...
Pengyun Li, Shengjie Cao, Yubing Huang, Yanan Zhang, Jie Liu, Xu Cai, Lulu Zhou, Jianbin Li, Zefei Jiang, Lihua Ding, Zhibing Zheng, Song Li, Qinong Ye   +12 more
doaj   +1 more source

Bioprinting of Multimaterials with Computer-aided Design/Computer-aided Manufacturing

International Journal of Bioprinting, 2020
Multimaterials deposition, a distinct advantage in bioprinting, overcomes material’s limitation in hydrogel-based bioprinting. Multimaterials are deposited in a build/support configuration to improve the structural integrity of threedimensional bioprinted construct.
Lee, Jia Min, Sing, Swee Leong, Yeong, Wai Yee   +2 more
openaire   +4 more sources

Supporting reinterpretation in computer-aided conceptual design [PDF]

, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder), Chase, S., EPSRC (Funder), Garner, S., Jowers, I., Lim, S., McKay, A., Prats, M.   +7 more
core  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source