Results 51 to 60 of about 615,084 (336)
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Algorithms for calculation damage processes
Fracture and Structural Integrity, 2019 The paper reviews the existing approaches to calculating the destruction of solids. The main attention is paid to algorithms using a unified approach to the calculation of deformation both for nondestructive and for the destroyed states of the material ...
Aleksandr Dmitrievich Nikitin +3 more
doaj
Essentials of DentistryBackground: Evaluating the prolonged efficacy of restorative materials hinges significantly on their ability to resist discoloration. This study aims to assess the discoloration resistance of computer-aided design/computer-aided manufacturing restorative
Rana Turunç Oğuzman +1 more
doaj +1 more source
Semi-Implicit Multistep Extrapolation ODE Solvers
Mathematics, 2020 Multistep methods for the numerical solution of ordinary differential equations are an important class of applied mathematical techniques. This paper is motivated by recently reported advances in semi-implicit numerical integration methods, multistep and
Denis Butusov +4 more
doaj +1 more source
Computer-aided design and analysis of mechanisms [PDF]
, 1982 An introduction to the computer programs developed to assist in the design and analysis of mechanisms is presented. A survey of the various types of programs which are available is given, and the most widely used programs are compared.
Knight, F. L.
core +1 more source
Computer-aided molecular design
Computer-Aided Design, 1985 Abstract Computer-aided molecular design has come of age. In the pharmaceutical and fine chemical industries computer graphics techniques allied to theoretical calculations are proving successful in suggesting to synthetic chemists molecules which will merit synthesis in terms of desired specific properties.
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics
Molecules, 2015 The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this ...
Benjamin P. Cossins +1 more
doaj +1 more source
Comparing Neural Style Transfer and Gradient-Based Algorithms in Brushstroke Rendering Tasks
Mathematics, 2023 Non-photorealistic rendering (NPR) with explicit brushstroke representation is essential for both high-grade imitating of artistic paintings and generating commands for artistically skilled robots.
Artur Karimov +5 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source