Results 61 to 70 of about 615,084 (336)

A two-stage multi-scale attention-based network for weakly supervised cataract fundus image enhancement

Scientific Reports
Cataract is a major cause of vision loss and hinders further diagnosis. However, enhancing cataract fundus images remains challenging due to limited paired cataract retinal images and the difficulty of recovering fine details in the retinal images.
Xiaoyong Fang, Yue Wang, Xiangyu Li, Wanshu Fan, Dongsheng Zhou   +4 more
doaj   +1 more source

A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein

Cell Death Discovery, 2021
Increasing evidence suggests the pivotal role of hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) in cancer development and progression, indicating that HPIP inhibition may be a promising target for cancer ...
Pengyun Li, Shengjie Cao, Yubing Huang, Yanan Zhang, Jie Liu, Xu Cai, Lulu Zhou, Jianbin Li, Zefei Jiang, Lihua Ding, Zhibing Zheng, Song Li, Qinong Ye   +12 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A modern course on digital design at the University of Twente [PDF]

, 1992
At the University of Twente, the Netherlands a modern course on basic digital design has been developed. This course, which is based on a text book in English (K. J.
Beusekamp, M.F.
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

MMTransformer: a multivariate time-series resource forecasting model for multi-component applications

Scientific Reports
Efficient resource forecasting in multi-component application scenarios necessitates comprehensive consideration of inter-component dependencies and resource interaction characteristics.
Guangzhang Cui, Tao Hu, Wei Zhang, Hujun Bao   +3 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Unraveling the multi-targeted curative potential of bioactive molecules against cervical cancer through integrated omics and systems pharmacology approach

Scientific Reports, 2022
Molecular level understanding on the role of viral infections causing cervical cancer is highly essential for therapeutic development. In these instances, systems pharmacology along with multi omics approach helps in unraveling the multi-targeted ...
Murali Aarthy, Pandiyan Muthuramalingam, Manikandan Ramesh, Sanjeev Kumar Singh   +3 more
doaj   +1 more source

Interactive graphical computer-aided design system [PDF]

, 1975
System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave
Edge, T. M.
core   +1 more source

Development of a STEP-compliant design and manufacturing framework for discrete sheet metal bend parts [PDF]

, 2016
Metal sheets have the ability to be formed into nonstandard sizes and sections. Displacement-controlled computer numerical control press brakes are used for three-dimensional sheet metal forming.
Ali, Liaqat, Baqai, Aamer Ahmed, Choudhry, Rizwan Saeed, Faraz, Zahid, Jaffery, Syed Husain Imran, Khan, Mushtaq, Mahmood, Khalid, Tarar, Wasim Akram, Waheed ul Haq, Syed   +8 more
core   +2 more sources