Results 71 to 80 of about 2,182,933 (405)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Using Computer Technology Tools to Improve the Teaching-Learning Process in Technical and Vocational Education: Mechanical Engineering Subject Area [PDF]

, 2009
This paper discusses the integration of computer assisted instructions (CAI) with traditional class room teaching. It describes a teaching method to bring real-world of industrial work into the classroom that underscores the need to learn fundamental ...
Abdulrasool, Salah Mahdi, Mishra, Rakesh
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Algorithms for calculation damage processes

Fracture and Structural Integrity, 2019
The paper reviews the existing approaches to calculating the destruction of solids. The main attention is paid to algorithms using a unified approach to the calculation of deformation both for nondestructive and for the destroyed states of the material ...
Aleksandr Dmitrievich Nikitin, Nikolay G. Burago, Ilia S. Nikitin, Boris A. Stratula   +3 more
doaj  

Computer Aided Design / Computer Aided Manufactur [CAD/CAM] [PDF]

, 2005
Computer-aided design (CAD) atau computer-aided design and drafting (CADD), merupakan satu bentuk otomatisasi yang membantu perancang untuk memperbaiki gambar, spesifikasi, dan elemen-elemen yang berhubungan dengan perancangan yang menggunakan efek ...
N, D. H. (Dewi)
core  

Functional programming for compiling and decompiling computer-aided design

Proc. ACM Program. Lang., 2018
Desktop-manufacturing techniques like 3D printing are increasingly popular because they reduce the cost and complexity of producing customized objects on demand. Unfortunately, the vibrant communities of early adopters, often referred to as "makers," are
Chandrakana Nandi, James R. Wilcox, P. Panchekha, Taylor Blau, D. Grossman, Zachary Tatlock   +5 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Multiuser Precoding for Sum-Rate Maximization in Relay-Aided mmWave Communications [PDF]

arXiv, 2020
Relay-aided transmission is envisioned as a key strategy to combat severe path loss and link blockages emerging as unique challenges in millimeter-wave (mmWave) communications. This work considers a relay-aided multiuser mmWave communications scenario aiming at maximizing the sum rate through optimal transmit and relay precoder design.
arxiv  

Generative Pre-Trained Transformer for Design Concept Generation: An Exploration [PDF]

arXiv, 2021
Novel concepts are essential for design innovation and can be generated with the aid of data stimuli and computers. However, current generative design algorithms focus on diagrammatic or spatial concepts that are either too abstract to understand or too detailed for early phase design exploration.
arxiv  

Space station models, mockups and simulators [PDF]

, 1985
Schematic outlines for space station models, mockups, and simulators are presented. The types of Boeing models, mockups, and simulators are given along with the classes and characteristics.
Miller, K. H., Osgood, A.
core   +1 more source