Results 101 to 110 of about 2,465,886 (354)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RAUM-GANs: a multi-layer GAN-enhanced framework for accurate multiple sclerosis lesion segmentation in MRI

Scientific Reports
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory brain lesions, making MRI-based lesion segmentation challenging due to noise, missing data, and limited availability of high-quality labeled images. This paper presents
Ahmed Alsayat, Ayman Mohamed Mostafa, Mahmoud Elmezain, Malak Alamri, Madallah Alruwaili, Mashail N. Alkhomsan, Menwa Alshammeri, Mohamed Ezz, Saleh Alharbi, Elsayed Mostafa, Wael Said   +10 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimized YOLOv8 for enhanced breast tumor segmentation in ultrasound imaging

Discover Oncology
Breast cancer significantly affects people’s health globally, making early and accurate diagnosis vital. While ultrasound imaging is safe and non-invasive, its manual interpretation is subjective.
Ayman Mohamed Mostafa, Alaa S. Alaerjan, Bader Aldughayfiq, Hisham Allahem, Alshimaa Abdelraof Mahmoud, Wael Said, Hosameldeen Shabana, Mohamed Ezz   +7 more
doaj   +1 more source

NASA Tech Briefs, August 2000 [PDF]

Topics include: Simulation/Virtual Reality; Test and Measurement; Computer-Aided Design and Engineering; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery/Automation ...

core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Realtime Student Information Center Application Based on Telegram Bot Case Study at the Faculty of Computer Science, UPN “Veteran” East Java

, 2020
Rizki Parlika, Arista Pratama
openalex   +1 more source

NASA Tech Briefs, November 2000 [PDF]

Topics covered include: Computer-Aided Design and Engineering; Electronic Components and Circuits; Electronic Systems; Test and Measurement; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery/Automation; Manufacturing/Fabrication ...

core   +1 more source