Results 71 to 80 of about 30,783 (226)
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
Abstract Background: Individuals with severe visual impairments frequently refrain from regular physical activity due to multiple barriers, including transportation difficulties, financial constraints, and limited availability of exercise programs tailored to their needs. These factors often contribute to a gradual decline in mobility and independence.
Luca Correale +7 more
wiley +1 more source
The predatory effect of the honey‐buzzard affects the reproductive performance of Asian‐hornet colonies, decreasing the density of workers over distance and time. The foraging distances of the honey‐buzzard concentrates within the first 2000 m from nest, which supports the results observed.
Jorge Ángel Martín‐Ávila +3 more
wiley +1 more source
Data reduction and data mining framework for digital forensic evidence: storage, intelligence, review and archive [PDF]
With the volume of digital forensic evidence rapidly increasing, this paper proposes a data reduction and data mining framework that incorporates a process of reducing data volume by focusing on a subset of information.
Darren Quick, Kim-Kwang Raymond Choo
core
ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino +3 more
wiley +1 more source
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler +7 more
wiley +1 more source
ABSTRACT Rationale Poly (acrylates)s can be distinguished from one another by the nature of their side chains. From model poly (acrylates)s, the purpose of this work was to evaluate the contribution of alternative activation techniques to the collisional activation, based on ion–ion and ion–photon interactions.
Inès Aloui +5 more
wiley +1 more source
ABSTRACT Rationale Hemicelluloses are abundant carbohydrate components in plant cell walls. They play a crucial structural role in binding cellulose microfibrils, in addition to other biological functions. Their high structural variability directly influences their biological properties, making it important to establish a structure–function ...
Rania Benazza +3 more
wiley +1 more source
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont +9 more
wiley +1 more source

