Results 81 to 90 of about 665,001 (310)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Applications of artificial intelligence in orthopaedic surgery

open access: yesFrontiers in Medical Technology, 2022
The practice of medicine is rapidly transforming as a result of technological breakthroughs. Artificial intelligence (AI) systems are becoming more and more relevant in medicine and orthopaedic surgery as a result of the nearly exponential growth in ...
Faraz Farhadi   +6 more
doaj   +1 more source

Quantum Genetics, Quantum Automata and Quantum Computation [PDF]

open access: yes, 2004
The concepts of quantum automata and quantum computation are studied in the context of quantum genetics and genetic networks with nonlinear dynamics. In a previous publication (Baianu,1971a) the formal concept of quantum automaton was introduced and its ...
Baianu, Professor I. C.
core  

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

A Survey on Optimal Transport for Machine Learning: Theory and Applications

open access: yesIEEE Access
Optimal Transport (OT) theory has seen increasing attention from the computer science community due to its potency and relevance in modeling and machine learning (ML).
Luiz Manella Pereira, M. Hadi Amini
doaj   +1 more source

Properties of CAD/CAM 3D Printing Dental Materials and Their Clinical Applications in Orthodontics: Where Are We Now?

open access: yesApplied Sciences, 2022
In the last years, both medicine and dentistry have come across a revolution represented by the introduction of more and more digital technologies for both diagnostic and therapeutic purposes.
Andrea Scribante   +8 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Social Media: A Review and Tutorial of Applications in Medicine and Health Care

open access: yesJournal of Medical Internet Research, 2014
Background Social media are dynamic and interactive computer-mediated communication tools that have high penetration rates in the general population in high-income and middle-income countries.
F. Grajales   +4 more
semanticscholar   +1 more source

Automation of Knowledge Work in Medicine and Health care: Future and Challenges

open access: yesInternational Journal of Body, Mind and Culture, 2017
Increment of computing speed, machine learning and human interface, have extended capabilities of artificial intelligence applications to an important stage. It is predicted that use of artificial intelligence (AI) to automate knowledge-based occupations
Farzan Majidfar
doaj  

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

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