Results 151 to 160 of about 5,737,648 (349)

Functional Integration of Different‐Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis

Advanced Biology, EarlyView.
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Daniel R. Pfau, Monica A. Rionda, Evelyn Cho, Jamison G. Clark, Robin E. Kruger, Ruth K. Chan‐Sui, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov   +8 more
wiley   +1 more source

IEEE Computer Architecture Letters [PDF]

, 2022

openalex   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating

Advanced Biology, EarlyView.
This study explores how magnesium–calcium coatings on titanium promote osteogenesis by releasing ions and elevating pH during degradation. Using osteoblast‐like cells, the research demonstrates that both ion release and pH changes contribute to cell proliferation, differentiation, and mineralization, offering new insights into the design of bioactive ...
Risa Miyake, Masaya Shimabukuro, Masahiko Terauchi, Eriko Marukawa, Masakazu Kawashita   +4 more
wiley   +1 more source

Microprogrammable computer architecture design considerations [PDF]

, 1980
William J. Tracz
openalex   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

New Developments in the Field of Production and Application of Multi‐Material Wire Arc Additive Manufacturing Components: A Review

Advanced Engineering Materials, EarlyView.
The utilization of direct energy deposition (DED)‐arc additive manufacturing processes in industrial applications is increasing, and these processes have the potential for multi‐material applications. This work provides a overview of the state of research in DED‐arc made functional graded structures, to establish a link to potential industrial ...
Kai Treutler, Volker Wesling
wiley   +1 more source

Fabrication‐Directed Entanglement for Designing Chiral and Anisotropic Metamaterial Foams

Advanced Engineering Materials, EarlyView.
This work introduces fabrication‐directed entanglement (FDE), combining viscous thread printing and topology optimization to program entangled foams with spatially patterned stiffness. By tuning coil density, FDE enables anisotropy, programmable Poisson's ratio, and chirality in foams.
Daniel Revier, Brett Emery, Jacob Miske, Jeffrey Lipton   +3 more
wiley   +1 more source

On the Application-ware of Computer in Landscape Architecture

, 1982
Satoshi Shiota
openalex   +2 more sources