Results 141 to 150 of about 3,233,520 (305)

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang   +7 more
wiley   +1 more source

Correlations without causation do not support claims of human-LLM reasoning alignment. [PDF]

open access: yesProc Natl Acad Sci U S A
Vankov II   +4 more
europepmc   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins   +23 more
wiley   +1 more source

Relationships among tissues, biofluids, and otolith selenium concentrations in wild female burbot (Lota lota)

open access: yesIntegrated Environmental Assessment and Management, EarlyView., 2023
Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves   +6 more
wiley   +1 more source

Factoring an integer with three oscillators and a qubit. [PDF]

open access: yesNat Commun
Brenner L   +3 more
europepmc   +1 more source

The professionalisation of teachers in France at a time of new reform: A comparative perspective of teacher‐trainers and students in pre‐service training

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The latest reform of initial teacher education (ITE) in France, introduced in 2021, aims to make teacher training less theoretical and therefore more ‘practical’. New elements, such as the replacement of the Écoles Supérieures pour le Professorat et l'Éducation (ÉSPÉs) by the Instituts Nationaux Supérieurs du Professorat et de l'Education ...
Eric Maleyrot, Thérèse Perez‐Roux
wiley   +1 more source

The Case of the Missing Green Iguana Predators: Reviews of Ecological Literature Should Go Beyond Google Scholar

open access: yesThe Bulletin of the Ecological Society of America, EarlyView.
Abstract Knowing about species interactions is essential for ecological research, conservation efforts, resource management, and maintaining healthy ecosystems, but many of these, such as reports of predation, may not always be published in easily located resources—if they are published at all.
Matthijs P. van den Burg, Hinrich Kaiser
wiley   +1 more source

Are Mathematical and Musical Abilities Related Beyond Intelligence? [PDF]

open access: yesJ Intell
Meier MA   +6 more
europepmc   +1 more source

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