Results 151 to 160 of about 85,791 (304)

Computer-Assisted Drug Therapy Problem Notification

Objective: To describe the use of computer technology to enhance our ability to identify and notify providers of potential drug therapy problems using a mail intervention monitoring programme. Setting: Pharmacy benefit management company.
Yvette J. Crockell, Nancy P. England, Ronald A. Lyon   +2 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Artificial intelligence in rehabilitation: a review of clinical effectiveness, real-world performance, safety, and equity across modalities and settings. [PDF]

Front Digit Health
Abdalla N, El Arab RA, Abdrbo A, Almari M, Ayoub MY, Alsaaideh B, Dagamseh MS, Almagharbeh WT, Abuadas F, Abu Mahfouz MS, Gaballah MK.   +10 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin. [PDF]

Sci Rep
Dabrosin N, Abrahamsson A, Kratz G.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Artificial Intelligence in Botulinum Toxin Injections: A Mini-Review of Current Applications, Challenges, and Translational Perspectives. [PDF]

Cureus
Xu Q, Jia C, Xia X, Xu N, Liu J.
europepmc   +1 more source

Dissemination of Computer-assisted Cognitive-behavior Therapy for Depression in Primary Care

, 2018
Computer-assisted cognitive-behavior therapy (CCBT) for depression in primary care will be evaluated in a trial with 240 patients randomly assigned to CCBT or treatment as usual (TAU).
Owen, Jesse J., Williams, Sara M., Wright, Brent, Harris, Lesley M., Antle, Becky F., Cappiccie, Amy, Eells, Tracy D., Wright, Jesse H., Wells, Michael J.   +8 more
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Artificial Intelligence in Gastrointestinal Endoscopy and Hemostatic Decision-Making: Current Evidence, Clinical Implications and Implementation Barriers. [PDF]

Life (Basel)
Brusnic O, Boicean A, Ichim C, Anderco P, Onisor D.   +4 more
europepmc   +1 more source