Results 91 to 100 of about 26,777,310 (288)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Exascale computing and big data
Communications of the ACM, 2015 Scientific discovery and engineering innovation requires unifying traditionally separated high-performance computing and big data analytics.
Reed, Daniel A., Dongarra, Jack
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
An electro-optic half subtractor from a silicon-based hybrid surface plasmon polariton waveguide
Open PhysicsIn order to solve the problems of low transmission rate and large device size of electro-optical modulator, an electro-optic half subtractor based on silicon-based hybrid surface plasmon polariton waveguide is proposed in this study.
Liang Zhixun +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Scientific DataOntologies have gained popularity in the scientific community as a way to standardize terminologies in organizations’ data. Although certain cohorts have created frameworks with rules and guidelines on creating ontologies, there exist significant ...
Balashanmuga Priyan Rajamohan +27 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Electro-Optic Toffoli Logic Based on Hybrid Surface Plasmons
PhotonicsReversible gates theoretically do not result in energy loss during the calculation process. The Toffoli gate is a universal reversible logic gate, and any reversible circuit can be constructed from the Toffoli gate.
Zhixun Liang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Social media spammer identification using deep learning [PDF]
MATEC Web of ConferencesSocial media has become a part of our lives with countless individuals actively sharing content and connecting with others. However this open platform also presents a challenge, in dealing with misinfor- mation and the spread of information by ...
Santhosh Kumar Ch.N. +4 more
doaj +1 more source