Results 91 to 100 of about 4,224,352 (310)

Computational protein design [PDF]

Nature Reviews Methods Primers
Combining molecular modelling, machine-learned models and an increasingly detailed understanding of protein chemistry and physics, computational protein design and human expertise have been able to produce new protein structures, assemblies and functions that do not exist in nature. Currently, generative deep-learning-based methods, which exploit large
Katherine I. Albanese, Sophie Barbe, Shunsuke Tagami, Derek N. Woolfson, Thomas Schiex   +4 more
openaire   +2 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Efficient workflow scheduling using an improved multi-objective memetic algorithm in cloud-edge-end collaborative framework

Scientific Reports
With the rapid advancement of large-scale model technologies, AI agent frameworks built on foundation models have become a central focus of artificial-intelligence research.
Guangzhang Cui, Wei Zhang, Weiwei Xu, Hujun Bao   +3 more
doaj   +1 more source

Performance Analysis of IndoBERT for Detection of Online Gambling Promotion in YouTube Comments

Engineering Proceedings
The proliferation of online gambling promotions on social media platforms, particularly YouTube, poses a significant challenge in digital security and regulation.
Kamdan Kamdan, Malik Pajar Anugrah, Moh Jeli Almutaali, Restu Ramdani, Ivana Lucia Kharisma   +4 more
doaj   +1 more source

Theoretical Study of Charge Mobility in Crystal Porphine and a Computer Design of a Porphine-Based Semiconductive Discotic Liquid Mesophase. [PDF]

Int J Mol Sci, 2023
Savintseva L, Avdoshin A, Ignatov S, Novikov A.   +3 more
europepmc   +1 more source

Techniques for improving reliability of computers [PDF]

, 1972
Modular design techniques improve methods of error detection, diagnosis, and recovery. Theoretical computer (MARCS (Modular Architecture for Reliable Computer Systems)) study deals with postulated and modeled technology indigenous to 1975-1980.
Bouricius, W. G., Cater, W. C., Jessep, D. C., Mccarthy, C. E., Milligan, F. G., Wadia, A. B.   +5 more
core   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Implementation of the VGG19 Model with Transfer Learning for Retinal Disease Diagnosis: A Study on Normal Eyes, Diabetic Retinopathy, Cataract, and Glaucoma Datasets

Engineering Proceedings
Retinal disorders, such as diabetic retinopathy, cataract, and glaucoma, are among the leading causes of vision loss and blindness worldwide. The use of normal data in diagnostic studies provides a basis for distinguishing between pathological and ...
Ivana Lucia Kharisma, Susanti, Rustiani, Riski Abdilah Pratama, Kamdan   +4 more
doaj   +1 more source

Computational design of metallohydrolases

Nature
De novo enzyme design seeks to build proteins containing ideal active sites with catalytic residues surrounding and stabilizing the transition state(s) of the target chemical reaction. The generative artificial intelligence method RFdiffusion solves this problem, but requires specifying both the sequence position and backbone coordinates for each ...
Donghyo Kim, Seth M. Woodbury, Woody Ahern, Doug Tischer, Alex Kang, Emily Joyce, Asim K. Bera, Nikita Hanikel, Saman Salike, Rohith Krishna, Jason Yim, Samuel J. Pellock, Anna Lauko, Indrek Kalvet, Donald Hilvert, David Baker   +15 more
openaire   +3 more sources

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source