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Angewandte Chemie International Edition, 2013
Abstract Recent developments in computational chemistry and biology have come together in the “inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze reactions not previously accelerated in nature. Some of these proteins fold and act as catalysts, but the success rate is still low.
Gert, Kiss +4 more
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Abstract Recent developments in computational chemistry and biology have come together in the “inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze reactions not previously accelerated in nature. Some of these proteins fold and act as catalysts, but the success rate is still low.
Gert, Kiss +4 more
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Designing Computational Materiality
Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems, 2019This paper articulates the design, manufacturing, and deployment of transTexture, a digital lamp features dynamic changing textures and changeable lighting effects. We deployed transTexture in the homes of two domain expert participants in a preliminary study to explore how computational materiality of interaction can fit a changing everyday ...
Zhong, Ce +3 more
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Computer Design in Computational Mechanics
2009 International Conference on Computing, Engineering and Information, 2009The computational mechanics suffers a lack of modifiability and interactivity, which leads to neglecting its potential to help engineers in solving problems faster and cheaper. The fully integration of computer design in computational mechanics will tackle this problems, by means of providing the capability to explore design variations within an ...
Serna S.P., Stork A.
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"Protein Engineering, Design and Selection", 1992
A computer program, which runs on MS-DOS personal computers, is described that assists in the design of synthetic genes coding for proteins. The goal of the program is the design of a gene which (i) contains as many unique restriction sites as possible and (ii) uses a specific codon usage.
Libertini G., DI DONATO, ALBERTO
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A computer program, which runs on MS-DOS personal computers, is described that assists in the design of synthetic genes coding for proteins. The goal of the program is the design of a gene which (i) contains as many unique restriction sites as possible and (ii) uses a specific codon usage.
Libertini G., DI DONATO, ALBERTO
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2019
The contemporary material culture—everyday objects surrounding us—is dominated by mass manufactured products, but Digital Fabrication together with Computational Design (also called generative or parametric design) promises a shift towards substantially personalizable products, in a relatively cost-effective way.
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The contemporary material culture—everyday objects surrounding us—is dominated by mass manufactured products, but Digital Fabrication together with Computational Design (also called generative or parametric design) promises a shift towards substantially personalizable products, in a relatively cost-effective way.
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Computational design tools for integrated design
2010In an architectural conceptual sketching process, where an architect is workingwith the initial ideas for a design, the process is characterized by three phases: sketching, evaluation and modification. Basically the architect needs to address three areas in the conceptual sketching phase: aesthetical, functional and technical requirements.
Holst, Malene Kirstine +1 more
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Computational Sequence Design with R2oDNA Designer
2017Recently developed DNA assembly methods have enabled the rapid and simultaneous assembly of multiple parts to create complex synthetic gene circuits. A number of groups have proposed the use of computationally designed orthogonal spacer sequences to guide the ordered assembly of parts using overlap-directed or homologous recombination-based methods ...
James T, MacDonald, Velia, Siciliano
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Computational design of antibodies
Current Opinion in Structural Biology, 2018Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect.
Sharon, Fischman, Yanay, Ofran
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Patenting computer-designed peptides
Journal of Computer-Aided Molecular Design, 1998The problem of designing new peptides that possess specific properties, such as bactericidal activity, is of wide interest. Recently, attention has focused on the use of Computer-Aided Molecular Design techniques in parallel with more traditional 'synthesise and test' methods.
S, Patel +3 more
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Computational Multitarget Drug Design
Journal of Chemical Information and Modeling, 2017Designing drugs that can simultaneously interact with multiple targets is a promising approach for treating complicated diseases. Compared to using combinations of single target drugs, multitarget drugs have advantages of higher efficacy, improved safety profile, and simpler administration.
Weilin Zhang, Jianfeng Pei, Luhua Lai
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