Results 161 to 170 of about 7,366,802 (374)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Journal of Electrical and Computer Engineering, 2023 Journal of Electrical and Computer Engineering
doaj +1 more source
The role of the host in a cooperating mainframe and workstation environment, volumes 1 and 2 [PDF]
In recent years, advancements made in computer systems have prompted a move from centralized computing based on timesharing a large mainframe computer to distributed computing based on a connected set of engineering workstations.
Kusmanoff, Antone, Martin, Nancy L.
core +1 more source
Boolean functions: with engineering applications and computer programs [PDF]
, 1989 Winfrid G. Schneeweiß
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Retracted: Association Rule Mining Algorithm in College Students’ Quality Evaluation System
Journal of Electrical and Computer Engineering, 2023 Journal of Electrical and Computer Engineering
doaj +1 more source
Integrated computer-aided engineering and design for DNA assemblies
Nature Materials, 2021 Chao-Min Huang +4 more
semanticscholar +1 more source
RIDL*: a tool for the computer-assisted engineering of large databases in the presence of integrity constraints [PDF]
, 1989 Olga De Troyer
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source