Results 11 to 20 of about 3,007,301 (331)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Proceedings of Abstracts Engineering and Computer Science Research Conference 2019 [PDF]

, 2019
© 2019 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adams, Roderick, Amafabia, Daerefa-a, Barker, Trevor, Beka, Nathan, Bhavsar, Ronakben, Bonivart, Agnes, Canoville, Paul, Cañamero, Lola, CHEN, Yong Kang, CHEN, Yong Kang, Chrysanthou, Andreas, Counsell, Nathan, Crook, Brian, Davey, Neil, David-West, Opukuro, Denai, Mouloud, Dhakal, Hom, Drix, Damien, Goncharenko, Julia, Grasso, Marzio, Hafner, Verena Vanessa, Hall, Samantha, Haritos, George, Hassan, Eheda, Helian, Na, Herfatmanesh, Mohammad Reza, Ismail, Sikiru O., Johnston, Ian, Johnston, Ian, Kadir, Shabnam, Kaye, Richard, Khan, Imran, Kirner, Raimund, Kirner, Raimund, Klaholz, Ingo, Klusak, Jan, Kourtessis, Pandelis, Lane, Peter, Lekkala, Himayasri Rao, Lilley, Mariana, Mayor, David, McCluskey, Daniel, McCluskey, Daniel, Menon, Catherine, Metzner, Christoph, Miko, Rebecca, Montalvão, Diogo, Mporas, Iosif, Munro, Ian, Nehaniv, Chrystopher, Newman, James, Nwawe, Richard, Panday, Deepak, Partou, Helen, Pissanidis, Georgios, Polani, Daniel, Ren, Guogang, Robinson, Matthew, Rosiello, Vincenzo, Sayers, Paul, Schilstra, Maria, Schirmer, Pascal, Schmuker, Michael, Siadati, Rana, Sinha, Ankur, Skaltsas, Grigorios, Steffert, Tony, Steuber, Volker, Steuber, Volker, Suckow, Bjorn, Sun, Yi, Sun, Yichuang, Sunmola, Funlade, Sutton, Samuel, te Boekhorst, Rene, Toffe, Gilles, Tracey, Mark, Tveretina, Olga, Veneziano, Vito, Verma, Alok, Wang, Yuan, Wernick, Paul   +81 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Software for Wearable Devices: Challenges and Opportunities

, 2015
Wearable devices are a new form of mobile computer system that provides exclusive and user-personalized services. Wearable devices bring new issues and challenges to computer science and technology.
Chen, Xin, Jiang, He, Kong, Weiqiang, Zhang, Shuwei, Zhang, Tao, Zhang, Xin   +5 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Using Experiential and Collaborative Learning to Promote Careers in Engineering [PDF]

, 2019
This paper discusses the design of the Girls Accelerating and Learning STEM (G.A.L.S.) one-week residential summer camp designed to encourage young girls to pursue engineering careers. Specifically, the camp exposed participants to the fields of computer
Frizell, Sherri, Nave, Felecia, Thompson, Audie, Williams, Rochelle   +3 more
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

THE RELATION BETWEEN THE INTENSITY OF THE USE OF COMPUTER LABORATORY FACILITY AND LEARNING MOTIVATION AND LEARNING RESULT OF INFORMATION AND COMMUNICATION TECHNOLOGY (TIK) OF GRADE XI COMPUTER AND NETWORK ENGINEERING IN SMK NEGERI 2 DEPOK SLEMAN ACADEMIC YEAR 2012/2013 [PDF]

, 2013
This study aimed to discover (1) the relation between intensity of the use of computer laboratory facility and TIK learning result of grade 11 computer and network engineering students of SMKN 2 Depok Sleman Academic Year 2012/2013, (2) the relation ...
Debbie Ahmad, Nusyera
core  

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source