Results 201 to 210 of about 7,637,119 (365)

Infological modeling method in knowledge engineering for solution of computer-aided design problems [PDF]

open access: bronze, 2017
A.G. Кorobeynikov   +3 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Synthetic multi-inversion time magnetic resonance images for visualization of subcortical structures. [PDF]

open access: yesJ Med Imaging (Bellingham)
Hays SP   +9 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Retracted: Blockchain Empowers Chain Enterprises in the Digital Economy to Strengthen Risk Management Research

open access: yesJournal of Electrical and Computer Engineering, 2023
Journal of Electrical and Computer Engineering
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Retracted: Application of an Improved LSTM Model to Emotion Recognition

open access: yesJournal of Electrical and Computer Engineering, 2023
Journal of Electrical and Computer Engineering
doaj   +1 more source

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