Results 41 to 50 of about 10,168,819 (309)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Computer Experiment in Teaching Mathematics
Doklady Mathematics, 2023 Abstract A mathematical experiment has always been a key source for a mathematical discovery. Over the past 50 years, thanks to digital technologies, its role in mathematical research has grown significantly. Digital technologies have opened up fundamentally new opportunities for experimentation in mathematics education,
G. B. Shabat, A. L. Semenov
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
WATERTUBE SMOKE TUBE BOILER: NUMERICAL COMPUTER SIMULATION AND EXPERIMENT
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018 The improvement of natural gas use technologies in water-heating boilers is considered. The concept of a new watertube smoke tube boiler, created on the basis of the screen radial tube bundle placement in the space of a cylindrical heat pipe-furnace. The
A. V. Kanygin
doaj +1 more source
Casting Technology Experiment and Computer Modeling of Ornaments from Bronze Age [PDF]
Archives of Metallurgy and Materials, 2018 The casting workshop was discovered with numerous artifacts, confirming the existence of the manufacturing process of metal ornaments using ceramic molds and investment casting technology in Lower Silesia (Poland) in 7-6 BC.
A. Garbacz-Klempka +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Statistical Theory and Related FieldsSpace-filling designs with superior low-dimensional properties are highly required in computer experiments. Strong orthogonal arrays (SOAs) represent a class of such designs that outperform ordinary orthogonal arrays in their stratification properties ...
Qiang Gao +3 more
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Optimal Control Methods of Experiment Times in System-of-Systems Combat Computer Simulation [PDF]
ITM Web of Conferences, 2019 In the process of scheme optimization, in order to eliminate the influence of random factor, it needs to conduct computer simulation of Monte Carlo. Therefore, it is proposed to introduce confidence interval into systemof-systems combat simulation, and ...
Zhao Zhiqiang, Zhou Feiyue
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source