Results 101 to 110 of about 414,610 (315)
Scientific ReportsAlzheimer’s Disease (AD) and related dementias are significant global health issues characterized by progressive cognitive decline and memory loss. Computer-aided systems can help physicians in the early and accurate detection of AD, enabling timely ...
Sepideh Zolfaghari +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Local Distributed Node for Power Quality Event Detection Based on Multi-Sine Fitting Algorithm
SensorsThe new power generation systems, the increasing number of equipment connected to the power grid, and the introduction of technologies such as the smart grid, underline the importance and complexity of the Power Quality (PQ) evaluation. In this scenario,
Domenico Luca Carní, Francesco Lamonaca
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
UML Modeling for Tea / Coffee Machine
, 2012 Unified Modeling language (UML) is one of the important modeling languages used for the visual representation of the research problem. In the present paper, UML model is designed for the Tea / Coffee Machine which is used for the purpose of the public in
Mr. H. Venkateswara Reddy +2 more
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Modern computer modeling tools [PDF]
, 2023 В праці розглядаються сучасні засоби комп'ютерного моделювання. Виконано систематизацію програмного забезпечення за галузями комп’ютерного моделювання та наведено приклади програмних засобів до кожної з груп.The article considers modern computer modeling
Твердохліб, Ігор Анатолійович +1 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Computer modelling of epilepsy [PDF]
Nature Reviews Neuroscience, 2008 Epilepsy is a complex set of disorders that can involve many areas of the cortex, as well as underlying deep-brain systems. The myriad manifestations of seizures, which can be as varied as déjà vu and olfactory hallucination, can therefore give researchers insights into regional functions and relations.
openaire +2 more sources
Keynote Address: Does the Future of Modeling and Simulation have a Game Face? [PDF]
, 2004 Proceedings of the 2004 Winter Simulation Conference R .G. Ingalls, M. D. Rossetti, J. S. Smith, and B. A. Peters, eds.The MOVES Institute’s mission is research, application and education in the grand challenges of modeling, virtual environments and ...
Zyda, Michael
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source