Results 261 to 270 of about 414,610 (315)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Computer-aided modeling of reactive systems

, 2008
Stewart, Warren E. 1924-, Caracotsios, Michael   +1 more
core  

Automated Computational Modeling.

, 2006
openaire   +2 more sources

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New Models of Computation

The Computer Journal, 2004
Summary: This paper examines the limitations of Turing Machines as a complete model of computation, and presents several models that extend Turing Machines. Dynamic interaction of clients and servers on the Internet, an infinite adaptation from evolutionary computation, and robots sensing and acting are some examples of areas that cannot be properly ...
Peter Wegner, Eugene Eberbach
openaire   +2 more sources

Models of Computation

2017
This book presents in their basic form the most important models of computation, their basic programming paradigms, and their mathematical descriptions, both concrete and abstract. Each model is accompanied by relevant formal techniques for reasoning on it and for proving some properties.
BRUNI, ROBERTO, MONTANARI, UGO GIOVANNI ERASMO   +1 more
openaire   +2 more sources

Computational Modeling in Human-Computer Interaction

Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems, 2019
We propose a workshop on rapidly emerging topic of Computational Modeling in HCI to address the challenges of increasing complexity of human behaviors we are able to track and collect today. The goal of this workshop is to reconcile two seemingly competing approaches to computational modeling: theoretical modeling, which seeks to explain behaviors vs ...
Nikola Banovic 0001, Antti Oulasvirta, Per Ola Kristensson   +2 more
openaire   +1 more source

Model-Based Computation

Natural Computing, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Putting the Computation Back into Computational Modeling

Pharmacopsychiatry, 2006
Many different varieties of modeling coexist in theoretical neuroscience. Here, we consider the positive and negative implications, for theories of schizophrenia, of a crucial distinction between computational and mathematical modeling.
P, Dayan, J, Williams
openaire   +2 more sources