Results 181 to 190 of about 3,311,825 (293)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Development of an Automatic Computer Program to Determine the Optimal Dental Implant Size and Position for Fibula Free Flap Surgery. [PDF]

Craniomaxillofac Trauma Reconstr
Cheung MY, Nayak A, Yu XN, Li KY, Su YX, Pu JJ.   +5 more
europepmc   +1 more source

Software modules of the computer program of reursion algorithm implementation for the case of variable input input parameters

, 2020
Oksana Kolysko, Mariana Sholudko
openalex   +1 more source

CSTRES. A computer program for evaluating the thermally induced interaction between helical tube bundles and their support plates. User's manual. [HTGR]

, 1978
Ho-Kil Woo
openalex   +2 more sources

Automated testing data reduction computer program [PDF]

The capability of a computer program which can be part of a larger computer program for a fully automated multiaxial testing facility is described.
Chamis, C. C., Kring, J., Sullivan, T. L.   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Accuracy and Reproducibility of Semidigital Versus Fully Digital Cephalometric Tracings Using a New Computer Program Versus Conventional Methods (Gold Standards): A Preliminary Study. [PDF]

Biomed Res Int
Sobouti F, Dadgar S, Namadian S, Bahrami Rad HR, Rakhshan V.   +4 more
europepmc   +1 more source

A Cognitive Based Approach To The Implementation Of The Introductory Computer Science Programming Sequence [PDF]

, 2020
Michael Doran, Herbert E. Longenecker, David Feinstein, David D. Langan   +3 more
openalex   +1 more source

Computer program documentation: ODRC demand plotting program user's guide [PDF]

The Orbital Data Reduction Center (ODRC) Demand Plotting Program provides the user with three main options, each of which provides the additional option of generating a numerical summary and/or plots for the Measurement ID's (MID) on the Measurement Node
Damico, S. J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source