Results 71 to 80 of about 7,861,380 (293)
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Development of a single cell spherical shell model for an investigation of electrical properties with a computing program [PDF]
A spherical double shell model (SDM) for a single cell has been developed, using Laplace’s equation in spherical coordinates and boundary conditions. Electric field intensities and dielectric constants of each region inside and outside of the cell have ...
Boonlamp, M., Bunthawin, S.
doaj
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Estimation of Reshaped Profile of Berm Breakwaters Using Experimental Data
A reshaping berm breakwater is a type of rubble mound breakwater in which, its seaward slope is allowed to reshape under wave attacks. There are some key parameters in the reshaped seaward profiles, which can schematize the reshaped profile of a berm ...
Alireza Sadat Hosseini, Mehdi Shafieefar
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Strategies for Simple One-Point Ko Situation of Computer Go [PDF]
[[abstract]]Ko plays a very important role in Go, but most computer Go programs still cannot handle ko fights so far. Utilizing the principle of Minimax procedure, we obtain the best strategies for the simple one-point ko situation, enabling computer Go ...
Lin, Shun-Shii;Huang, Shi-Jie;Yen, Shi-Jim
core

