Results 111 to 120 of about 10,000,180 (327)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Computer programs for reduction of microphotometer data [PDF]

Five computer programs for analyzing magnetic tape recordings of digital data from ...
Bell, R. A., Bengtson, R. D., Branch, D. R., Gottlieb, D. M., Roig, R.   +4 more
core   +1 more source

MZnet : mail service for personal micro-computer systems [PDF]

, 1984
Traditional computer mail systems involve a co-resident User Agent (UA) and Mail Transfer System (MTS) on a time-shared host computer which may be connected to other hosts ina network, with new mail posted or delivered directly through co-resident mail ...
Domae, Terrance, Stefferud, Einar, Sweet, Jerry   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Information security of computer games and problems associated with the protection of the rights of users and companies

Современная наука и инновации
One of the fastest growing areas in intellectual property is related to computer games. Games are more inherently related to the field of entertainment, but in addition they can affect the development of certain skills in players.
M. V. Osipova, M. Yu. Petrov
doaj   +1 more source

Shuttle environmental and thermal control/life support system computer program [PDF]

Computer programs developed to simulate the RSECS (representative shuttle environmental control system) are described. These programs were prepared to provide pretest predictions, post-test analysis and real-time problem analysis for RSECS test planning ...
Ayotte, W. J., Elfers, F. A.
core   +1 more source

Standardization and qualification of computer programs for circuit design [PDF]

, 1972
Study presents methods and initial procedures which may be obtained for development of more efficient uniform network analysis input language and theoretical tools to prove equivalence of data ...
Chow, T. S., Martin, D. F., Mcnamee, L. P., Meyerhoff, D. E.   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source