Results 41 to 50 of about 155,604 (315)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Prospects and Challenges of Artificial Intelligence and Computer Science for the Future of Urology [PDF]

World Journal of Urology, 2020
He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K (2019) The practical implementation of artificial intelligence technologies in medicine. Nat Med 25(1):30–36 CAS Article Google Scholar Frost and Sullivan 2016. From $600 M to $6 billion, artificial intelligence systems poised for dramatic market expansion in healthcare.
Suarez-Ibarrola, Rodrigo, Miernik, Arkadiusz   +1 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

LACE: Mitigating cold-starts in serverless with a multi-task mixture-of-experts caching

Journal of King Saud University: Computer and Information Sciences
Serverless computing has become a transformative cloud paradigm due to its operational simplicity, cost efficiency, and elastic scalability. Unfortunately, it suffers from cold-start problems caused by container initialization during the first function ...
Chunpu Huang, Yukai Huang, Jingqi Feng, Sicheng Liang, Ming Yan, Jie Wu   +5 more
doaj   +1 more source

Dynamic multi-constraint path planning of carrier-based aircraft based on deep reinforcement learning

Zhongguo Jianchuan Yanjiu
ObjectiveMost existing path planning methods for carrier-based aircraft fail to account for the practical spatial constraints encountered during their transfer process and have difficulty adapting to the highly dynamic conditions on the deck.
Shuo HE, Gaohuan XU, Yuanyuan JIN, Yafei LI, Tiantian LI, Hua WANG, Yibo GUO, Lulu LI, Mingliang XU   +8 more
doaj   +1 more source

Intelligent library systems: artificial intelligence technology and library automation systems [PDF]

, 1991
Artificial Intelligence (AI) encompasses the following general areas of research: (1) automatic programming, (2) computer vision, (3) expert systems, (4) intelligent computer-assisted instruction, (5) natural language processing, (6) planning and ...
Bailey, Jr., Charles W.
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Visions of Artificial Intelligence and Robots in Science Fiction: a computational analysis

International Journal of Social Robotics, 2022
AbstractDriven by the rapid development of artificial intelligence (AI) and anthropomorphic robotic systems, the various possibilities and risks of such technologies have become a topic of urgent discussion. Although science fiction (SF) works are often cited as references for visions of future developments, this framework of discourse may not be ...
Hirotaka Osawa, Dohjin Miyamoto, Satoshi Hase, Reina Saijo, Kentaro Fukuchi, Yoichiro Miyake   +5 more
openaire   +2 more sources

Learning models of sequential decision-making with partial specification of agent behavior

, 2019
Artificial agents that interact with other (human or artificial) agents require models in order to reason about those other agents’ behavior. In addition to the predictive utility of these models, maintaining a model that is aligned with an agent’s true ...
Shah, Julie A., Unhelkar, Vaibhav Vasant, Shah, Julie A, Unhelkar, Vaibhav V.   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source