Results 71 to 80 of about 202,825 (266)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Energy Harvesting-Based Smart Transportation Mode Detection System via Attention-Based LSTM
IEEE Access, 2019 Detecting the transportation mode of an individual's everyday travel provides useful information in urban design, real-time journey planning, and activity monitoring.
Weitao Xu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A New Approach to Teaching Mathematics in Universities
Открытое образование (Москва)The aim of this paper is to develop a methodology for teaching mathematics at universities that makes extensive use of modern digital and information technologies.
V F. Ochkov +2 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Complexity, 2019 Decomposition-based multiobjective evolutionary algorithms (MOEA/Ds) have become increasingly popular in recent years. In these MOEA/Ds, evolutionary search is guided by the used weight vectors in decomposition function to approximate the Pareto front ...
Wu Lin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Innovations in Computing Sciences and Software Engineering [PDF]
, 2010 Innovations in Computing Sciences and Software Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Sciences.
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A survey of the relevance of computer science and software engineering education [PDF]
Proceedings 11th Conference on Software Engineering Education, 2002 We describe a study of 168 software professionals to determine how relevant their education has been to their careers. Starting with a list of 57 topics, we asked the participants to indicate how much they learned in university, how much they know now, how useful the material has been and whether they would like to learn more.
openaire +1 more source