Results 121 to 130 of about 34,541,972 (297)

AGCD: An Attention-Guided Graph Convolution Network for Change Detection of Remote Sensing Images

open access: yesRemote Sensing
Change detection is a crucial field in remote sensing image analysis for tracking environmental dynamics. Although convolutional neural networks (CNNs) have made impressive strides in this field, their grid-based processing structures struggle to capture
Heng Li   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Complementary Local–Global Optimization for Few-Shot Object Detection in Remote Sensing

open access: yesRemote Sensing
Few-shot object detection (FSOD) in remote sensing remains challenging due to the scarcity of annotated samples and the complex background environments in aerial images.
Yutong Zhang   +7 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Computer forensics tertiary education in Australia

open access: yes, 2008
The number of Computer Forensics related courses in Australian universities tripled in the last three years. This unprecedented growth is fuelled by the growth of the discipline itself and the increase in demand for specialists by both law enforcement ...
Bem, Derek, Ruan, Chun, Huebner, Ewa Z.
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Advances in Computer Science and Engineering

open access: yes, 2012
This book includes the proceedings of the second International Conference on Advances in Computer Science and Engineering (CES 2012), which was held during January 13-14, 2012 in Sanya, China.
Zeng, Dehuai
core   +1 more source

The Influence of Software Engineering Education on Developing Teamwork Skills in Both Genders

open access: yesIEEE Access
Teamwork is recognized as a highly valuable skill for any software engineer. In computer science programs it is typically developed through project-based courses, though these courses often do not adopt a gender-oriented approach.
Maria Cecilia Bastarrica   +1 more
doaj   +1 more source

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