Results 81 to 90 of about 34,540,832 (298)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On Agent-Based Software Engineering [PDF]
, 1999 Agent-based computing represents an exciting new synthesis both for Artificial Intelligence (AI) and, more generally, Computer Science. It has the potential to significantly improve the theory and the practice of modeling, designing, and implementing ...
Jennings, N. R. +3 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A survey of the relevance of computer science and software engineering education [PDF]
Proceedings 11th Conference on Software Engineering Education, 2002 We describe a study of 168 software professionals to determine how relevant their education has been to their careers. Starting with a list of 57 topics, we asked the participants to indicate how much they learned in university, how much they know now, how useful the material has been and whether they would like to learn more.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Innovating at the Intersection: Software Engineering for Science and Industry
This paper provides a summary of the keynote talk ’Innovating at the Intersection: Software Engineering for Science and Industry’ held at the conference Software Engineering ...
Felderer, Michael
core +1 more source
Energy Harvesting-Based Smart Transportation Mode Detection System via Attention-Based LSTM
IEEE Access, 2019 Detecting the transportation mode of an individual's everyday travel provides useful information in urban design, real-time journey planning, and activity monitoring.
Weitao Xu +5 more
doaj +1 more source
Where's the science in software engineering?
Ubiquity, 2014 This article is a personal account of the methodological evolution of software engineering research from the 1970s to the present.
openaire +2 more sources
Innovations in Computing Sciences and Software Engineering [PDF]
, 2010 Innovations in Computing Sciences and Software Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Sciences.
openaire +1 more source