Results 31 to 40 of about 203,048 (266)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
QuickVol: A lightweight browser tool for immersive visualizations of volumetric data
iScienceSummary: Volumetric layouts of data are becoming increasingly common in a number of fields. Visualizing these data often requires downloading a large suite of dedicated tools with a significant learning curve.
Maxim Kuznetsov +3 more
doaj +1 more source
The Role of User Behaviour in Improving Cyber Security Management
Frontiers in Psychology, 2021 Information security has for long time been a field of study in computer science, software engineering, and information communications technology. The term ‘information security’ has recently been replaced with the more generic term cybersecurity.
Ahmed A. Moustafa +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Editorial: Applied Computing 2023
مجلة بغداد للعلومApplied computing utilizes aspects of computer science to solve problems in several disciplines, including business, politics, education, and the environment.
Yousra Abdul Alsahib S. Aldeen +2 more
doaj +1 more source
Освітній вимір, 2018 Tkachuk V.V., Shchokin V.P. and Tron V.V. The Model of Use of Mobile Information and Communication Technologies in Learning Computer Sciences to Future Professionals in Engineering Pedagogy.
Вікторія Ткачук +2 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
What Computing Curricula is Needed: A Case at the University of Latvia
Informatics in Education, 2004 Computer science undergraduate (bachelor) curriculum of the University of Latvia was developed in late 80th based on curricula of several US universities while keeping strong practical setting.
Juris BORZOVS
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source