Results 71 to 80 of about 1,943,038 (270)

Complex systems science: expert consultation report [PDF]

open access: yes, 2009
Executive SummaryA new programme of research in Complex Systems Science must be initiated by FETThe science of complex systems (CS) is essential to establish rigorous scientific principles on which to develop the future ICT systems that are critical to ...
Bourgine, Paul   +2 more
core  

Interests Diffusion in Social Networks

open access: yes, 2015
Understanding cultural phenomena on Social Networks (SNs) and exploiting the implicit knowledge about their members is attracting the interest of different research communities both from the academic and the business side.
D'Agostino, Gregorio   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Análisis de la producción y colaboración científica de Instituciones: el caso del Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas (IIMAS) de la Universidad Nacional Autónoma de México (UNAM)

open access: yesREDES: Revista Hispana para el Análisis de Redes Sociales, 2018
En este trabajo se presenta un perfil bibliométrico del área ciencias de la computación (CS por sus siglas en inglés Computer Science) del Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas a partir su producción científica indizada en ...
Alejandro Arnulfo Ruiz León
doaj   +1 more source

Reinforcement Learning: A Survey [PDF]

open access: yes, 1996
This paper surveys the field of reinforcement learning from a computer-science perspective. It is written to be accessible to researchers familiar with machine learning.
Kaelbling, L. P.   +2 more
core   +9 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

A Parameterisation of Algorithms for Distributed Constraint Optimisation via Potential Games

open access: yes, 2008
This paper introduces a parameterisation of learning algorithms for distributed constraint optimisation problems (DCOPs). This parameterisation encompasses many algorithms developed in both the computer science and game theory literatures. It is built on
Chapman, Archie   +2 more
core   +1 more source

На шляху до комп’ютерної математики [PDF]

open access: yes, 2011
Наведено результати дослідження нового напряму сучасної науки — комп’ютерної математики — з точки зору історичних, філософських, психологічних, методологічних та інших аспектів.
Джалладова, Ірада Агаєвна
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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