Results 31 to 40 of about 684,182 (254)
"Revolution? What Revolution?" Successes and limits of computing technologies in philosophy and religion [PDF]
, 2004 Computing technologies like other technological innovations in the modern West are inevitably introduced with the rhetoric of "revolution". Especially during the 1980s (the PC revolution) and 1990s (the Internet and Web revolutions), enthusiasts ...
Ess, Charles
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cyber-crime Science = Crime Science + Information Security [PDF]
, 2010 Cyber-crime Science is an emerging area of study aiming to prevent cyber-crime by combining security protection techniques from Information Security with empirical research methods used in Crime Science.
Hartel, Pieter +2 more
core +2 more sources
Simulating chemistry efficiently on fault-tolerant quantum computers [PDF]
, 2012 Quantum computers can in principle simulate quantum physics exponentially faster than their classical counterparts, but some technical hurdles remain. Here we consider methods to make proposed chemical simulation algorithms computationally fast on fault ...
+22 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Motivation, Design, and Ubiquity: A Discussion of Research Ethics and Computer Science
, 2006 Modern society is permeated with computers, and the software that controls them can have latent, long-term, and immediate effects that reach far beyond the actual users of these systems.
Wright, David R.
core +1 more source
Sistem Pengendalian Parkir Menggunakan Sensor Switch [PDF]
, 2013 Developments in science and technology is now becoming more sophisticated with the advent of modern tools, for example, is a computer. The use of computers in society is no stranger to either diperkantoran, homes, and other pasilitas.
Kalsum, T. U. (Toibah) +2 more
core
, 2013 On being promoted to a personal chair in 1993 I chose the title of Professor of Informatics, specifically acknowledging Donna Haraway’s definition of the term as the “technologies of information [and communication] as well as the biological, social ...
Bryant, A
core +2 more sources